TY - JOUR T1 - Impact of HCV infection and ethnicity on incident type 2 diabetes: findings from a large population-based cohort in British Columbia JF - BMJ Open Diabetes Research & Care JO - BMJ Open Diab Res Care DO - 10.1136/bmjdrc-2021-002145 VL - 9 IS - 1 SP - e002145 AU - Dahn Jeong AU - Mohammad Ehsanul Karim AU - Stanley Wong AU - James Wilton AU - Zahid Ahmad Butt AU - Mawuena Binka AU - Prince Asumadu Adu AU - Sofia Bartlett AU - Margo Pearce AU - Emilia Clementi AU - Amanda Yu AU - Maria Alvarez AU - Hasina Samji AU - Héctor Alexander Velásquez García AU - Younathan Abdia AU - Mel Krajden AU - Naveed Zafar Janjua Y1 - 2021/06/01 UR - http://drc.bmj.com/content/9/1/e002145.abstract N2 - Introduction Increasing evidence indicates that chronic hepatitis C virus (HCV) infection is associated with higher risk of diabetes. Previous studies showed ethnic disparities in the disease burden of diabetes, with increased risk in Asian population. We described the incidence of type 2 diabetes related to HCV infection and assessed the concurrent impact of HCV infection and ethnicity on the risk of diabetes.Research design and methods In British Columbia Hepatitis Testers Cohort, individuals were followed from HCV diagnosis to the earliest of (1) incident type 2 diabetes, (2) death or (3) end of the study (December 31, 2015). Study population included 847 021 people. Diabetes incidence rates in people with and without HCV were computed. Propensity scores (PS) analysis was used to assess the impact of HCV infection on newly acquired diabetes. PS-matched dataset included 117 184 people. We used Fine and Gray multivariable subdistributional hazards models to assess the effect of HCV and ethnicity on diabetes while adjusting for confounders and competing risks.Results Diabetes incidence rates were higher among people with HCV infection than those without. The highest diabetes incidence rate was in South Asians with HCV (14.7/1000 person-years, 95% CI 12.87 to 16.78). Compared with Others, South Asians with and without HCV and East Asians with HCV had a greater risk of diabetes. In the multivariable stratified analysis, HCV infection was associated with increased diabetes risk in all subgroups: East Asians, adjusted HR (aHR) 3.07 (95% CI 2.43 to 3.88); South Asians, aHR 2.62 (95% CI 2.10 to 3.26); and Others, aHR 2.28 (95% CI 2.15 to 2.42).Conclusions In a large population-based linked administrative health data, HCV infection was associated with higher diabetes risk, with a greater relative impact in East Asians. South Asians had the highest risk of diabetes. These findings highlight the need for care and screening for HCV-related chronic diseases such as type 2 diabetes among people affected by HCV.Data are available on reasonable request. Data are available from the BC Centre for Disease Control Institutional Data Access for researchers who meet the criteria for access to confidential data. Requests for the data may be sent to Dr Naveed Janjua (naveed.janjua@bccdc.ca). ER -