PT - JOURNAL ARTICLE AU - Lingwen Ying AU - Chaohui Jian AU - Xiaojing Ma AU - Kun Ge AU - Wei Zhu AU - Yufei Wang AU - Aihua Zhao AU - Jian Zhou AU - Wei Jia AU - Yuqian Bao TI - Saliva 1,5-anhydroglucitol is associated with early-phase insulin secretion in Chinese patients with type 2 diabetes AID - 10.1136/bmjdrc-2021-002199 DP - 2021 Jun 01 TA - BMJ Open Diabetes Research & Care PG - e002199 VI - 9 IP - 1 4099 - http://drc.bmj.com/content/9/1/e002199.short 4100 - http://drc.bmj.com/content/9/1/e002199.full SO - BMJ Open Diab Res Care2021 Jun 01; 9 AB - Introduction Saliva collection is a non-invasive test and is convenient. 1,5-anhydroglucitol (1,5-AG) is a new indicator reflecting short-term blood glucose levels. This study aimed to explore the relationship between saliva 1,5-AG and insulin secretion function and insulin sensitivity.Research design and methods Adult patients with type 2 diabetes who were hospitalized were enrolled. Based on blood glucose and C-peptide, homeostasis model assessment 2 for β cell secretion function, C-peptidogenic index (CGI), △2-hour C-peptide (2hCP)/△2-hour postprandial glucose (2hPG), ratio of 0–30 min area under the curve for C-peptide and area under the curve for glucose (AUCCP30/AUCPG30), and AUC2hCP/AUC2hPG were calculated to evaluate insulin secretion function, while indicators such as homeostasis model assessment 2 for insulin resistance were used to assess insulin sensitivity.Results We included 284 subjects (178 men and 106 women) with type 2 diabetes aged 20–70 years. The saliva 1,5-AG level was 0.133 (0.089–0.204) µg/mL. Spearman’s correlation analysis revealed a significantly negative correlation between saliva 1,5-AG and 0, 30, and 120 min blood glucose, glycated hemoglobin A1c, and glycated albumin (all p<0.05), and a significantly positive association between saliva 1,5-AG and CGI (r=0.171, p=0.004) and AUCCP30/AUCPG30 (r=0.174, p=0.003). The above correlations still existed after adjusting for age, sex, body mass index, and diabetes duration. In multiple linear regression, saliva 1,5-AG was an independent factor of CGI (standardized β=0.135, p=0.015) and AUCCP30/AUCPG30 (standardized β=0.110, p=0.020).Conclusions Saliva 1,5-AG was related to CGI and AUCCP30/AUCPG30 in patients with type 2 diabetes.Trial registration number ChiCTR-SOC-17011356.Data are available on reasonable request. The datasets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.