RT Journal Article
SR Electronic
T1 Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e001865
DO 10.1136/bmjdrc-2020-001865
VO 9
IS 1
A1 Jirapitcha Boonpor
A1 Solange Parra-Soto
A1 Fanny Petermann-Rocha
A1 Gerson Ferrari
A1 Paul Welsh
A1 Jill P Pell
A1 Naveed Sattar
A1 Jason Martin Regnald Gill
A1 Frederick K Ho
A1 Stuart Robert Gray
A1 Carlos Celis-Morales
YR 2021
UL http://drc.bmj.com/content/9/1/e001865.abstract
AB Introduction Grip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim of this study was to investigate the associations of absolute and relative grip strength with incident T2DM and whether these associations differ by sociodemographic, lifestyle and adiposity-related factors.Research design and methods This was a prospective cohort study of 166 894 participants in the UK Biobank (mean age 56.5 years, 54.4% women). The outcome was T2DM incidence and the exposure was grip strength, expressed in absolute (kg) and relative (kg per kg of body weight) values. The association between grip strength and T2DM incidence was investigated using Cox-proportional regression.Results The median follow-up was 5.3 years (IQR: 4.7–6.1). During this time, 3713 participants developed T2DM. Lower grip strength was associated with a higher risk of T2DM in both sexes. Those in the lowest quintile of absolute grip strength had a 50% higher risk in men (HR: 1.50 (95% CI: 1.30 to 1.73)) and 25% higher risk in women (HR: 1.25 (95% CI: 1.06 to 1.47)) compared with those in the highest quintile. For relative grip strength, risk of diabetes was more than double for men (HR: 2.22 (95% CI: 1.84 to 2.67)) and 96% higher for women (HR: 1.96 (95% CI: 1.52 to 2.53)) in the lowest compared with highest quintiles.Conclusions Grip strength is associated with a higher risk of T2DM incidence in both men and women independent of important confounding factors including age, deprivation, adiposity and lifestyle. However, the associations were stronger when grip strength is expressed relative to body weight, which could reflect the importance of muscle quality.Data are available upon reasonable request. Data can be obtained upon request to UK Biobank.