TY - JOUR T1 - Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank: implications for screening JF - BMJ Open Diabetes Research & Care JO - BMJ Open Diab Res Care DO - 10.1136/bmjdrc-2021-002176 VL - 9 IS - 1 SP - e002176 AU - Jana J Anderson AU - Paul Welsh AU - Frederick K Ho AU - Lyn D Ferguson AU - Claire E Welsh AU - Pierpaolo Pellicori AU - John G F Cleland AU - John Forbes AU - Stamatina Iliodromiti AU - James Boyle AU - Robert Lindsay AU - Carlos Celis-Morales AU - Stuart Robert Gray AU - Srinivasa Vittal Katikireddi AU - Jason Martin Regnald Gill AU - Jill P Pell AU - Naveed Sattar Y1 - 2021/08/01 UR - http://drc.bmj.com/content/9/1/e002176.abstract N2 - Introduction Early detection and treatment of diabetes as well as its prevention help lessen longer-term complications. We determined the prevalence of pre-diabetes and undiagnosed diabetes in the UK Biobank and standardized the results to the UK general population.Research design and methods This cross-sectional study analyzed baseline UK Biobank data on plasma glycated hemoglobin (HbA1c) to compare the prevalence of pre-diabetes and undiagnosed diabetes mellitus in white, South Asian, black, and Chinese participants. The overall and ethnic-specific results were standardized to the UK general population aged 40–70 years of age.Results Within the UK Biobank, the overall crude prevalence was 3.6% for pre-diabetes, 0.8% for undiagnosed diabetes, and 4.4% for either. Following standardization to the UK general population, the results were similar at 3.8%, 0.8%, and 4.7%, respectively. Crude prevalence was much higher in South Asian (11.0% pre-diabetes; 3.6% undiagnosed diabetes; 14.6% either) or black (13.8% pre-diabetes; 3.0% undiagnosed diabetes; 16.8% either) participants. Only six middle-aged or old-aged South Asian individuals or seven black would need to be tested to identify an HbA1c result that merits action.Conclusions Single-stage population screening for pre-diabetes or undiagnosed diabetes in middle-old or old-aged South Asian and black individuals using HbA1c could be efficient and should be considered.Data may be obtained from a third party and are not publicly available. UK Biobank data can be requested by bona fide researchers for approved projects, including replication, through https://www.ukbiobank.ac.uk/. ER -