TY - JOUR T1 - Iron parameters in patients with partial lipodystrophy and impact of exogenous leptin therapy JF - BMJ Open Diabetes Research & Care JO - BMJ Open Diab Res Care DO - 10.1136/bmjdrc-2021-002385 VL - 9 IS - 1 SP - e002385 AU - Efe Y Akinci AU - Sabine Boutros AU - Benjamin J Ryan AU - Pinar Sargin AU - Baris Akinci AU - Adam H Neidert AU - Rita Hench AU - Jeffrey F Horowitz AU - Elif A Oral Y1 - 2021/08/01 UR - http://drc.bmj.com/content/9/1/e002385.abstract N2 - Provocative rodent studies taken together with cross-sectional human epidemiological data have shown that there may be a cross-talk between circulating leptin levels and whole-body iron metabolism.1 2 In this study, we aim to discover the effects of recombinant leptin administration on iron parameters in patients with partial lipodystrophy.We studied serum samples from 19 patients with partial lipodystrophy (median age: 42 years, IQR: 34–57, male/female: 3/16) gathered from an open-label study previously performed at the University of Michigan (ClinicalTrials.gov identifier: NCT01679197; article in press). All patients included in this analysis had familial partial lipodystrophy. We measured iron (assay range: 5–1000 µg/dL), soluble transferrin receptor (sTfR; assay range: 3.0–80.0 nmol/L), hepcidin (assay range: 2.5–1000 ng/mL), and high-sensitive C reactive protein (hs-CRP; assay range 0.1–80 mg/L) levels using commercially available assays. We integrated the results into an existing database of metabolic parameters. Repeated-measures analysis of variance was used to compare multiple time points. Paired t-test was used to compare month 6 values to baseline (a prespecified endpoint). Otherwise, multiplicity correction was performed. Normality was assessed by the Kolmogorov-Smirnov test and the Shapiro-Wilk’s W test and also by plotting a histogram of the variable of interest. Log transformation was used for skewed data. Data are presented as median, IQR.At baseline, ferritin levels were positively correlated with fasting glucose (r=0.533; p=0.023; figure 1A) and HbA1c (r=0.510; p=0.031; figure 1B). We … ER -