TY - JOUR T1 - Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women JF - BMJ Open Diabetes Research & Care JO - BMJ Open Diab Res Care DO - 10.1136/bmjdrc-2021-002321 VL - 9 IS - 2 SP - e002321 AU - Yao Su AU - Xu-Pei Gan AU - Fei-Fei Li AU - Dong-Yao Zhang AU - Li Chen AU - Yan-Nan Cao AU - Hong-Hui Qiu AU - De-Cui Cheng AU - Jian-Fei Zu AU - Wen-Yu Liu AU - Hong-Kun Wang AU - Xian-Ming Xu Y1 - 2021/11/01 UR - http://drc.bmj.com/content/9/2/e002321.abstract N2 - Introduction Exposure to antibiotics (ABX) during pregnancy can have a systematic effect on both fetal and maternal health. Although previous biomonitoring studies have indicated the effects on children of extensive exposure to ABX, studies on pregnant women remain scarce. To explore the effect on pregnant women of environmental exposure to ABX through accidental ingestion and identify potential health risks, the present study investigated 122 pregnant women in East China between 2019 and 2020.Research design and methods The presence of six categories of ABX (quinolones, sulfonamides, lincosamides, tetracyclines, amide alcohol ABX, and β-lactams) in plasma samples taken from the pregnant women was investigated using an ABX kit and a time-resolved fluorescence immunoassay.Results All six ABX were detected in the plasma, with a detection rate of 17.2%. It was discovered that the composition of intestinal flora in pregnant women exposed to ABX was different from that of pregnant women who had not been exposed to ABX. The intestinal flora of pregnant women exposed to ABX also changed at both the phylum and genus levels, and several genera almost disappeared. Furthermore, the metabolic levels of glucose and insulin and the alpha diversity of pregnant women exposed to ABX were higher than those of pregnant women not exposed to ABX.Conclusion Pregnant women are potentially at higher risk of adverse microbial effects. Glucose metabolism and insulin levels were generally higher in pregnant women exposed to ABX than in unexposed women. Also, the composition and color of the gut microbiome changed.All data relevant to the study are included in the article. ER -