RT Journal Article
SR Electronic
T1 Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e002321
DO 10.1136/bmjdrc-2021-002321
VO 9
IS 2
A1 Yao Su
A1 Xu-Pei Gan
A1 Fei-Fei Li
A1 Dong-Yao Zhang
A1 Li Chen
A1 Yan-Nan Cao
A1 Hong-Hui Qiu
A1 De-Cui Cheng
A1 Jian-Fei Zu
A1 Wen-Yu Liu
A1 Hong-Kun Wang
A1 Xian-Ming Xu
YR 2021
UL http://drc.bmj.com/content/9/2/e002321.abstract
AB Introduction Exposure to antibiotics (ABX) during pregnancy can have a systematic effect on both fetal and maternal health. Although previous biomonitoring studies have indicated the effects on children of extensive exposure to ABX, studies on pregnant women remain scarce. To explore the effect on pregnant women of environmental exposure to ABX through accidental ingestion and identify potential health risks, the present study investigated 122 pregnant women in East China between 2019 and 2020.Research design and methods The presence of six categories of ABX (quinolones, sulfonamides, lincosamides, tetracyclines, amide alcohol ABX, and β-lactams) in plasma samples taken from the pregnant women was investigated using an ABX kit and a time-resolved fluorescence immunoassay.Results All six ABX were detected in the plasma, with a detection rate of 17.2%. It was discovered that the composition of intestinal flora in pregnant women exposed to ABX was different from that of pregnant women who had not been exposed to ABX. The intestinal flora of pregnant women exposed to ABX also changed at both the phylum and genus levels, and several genera almost disappeared. Furthermore, the metabolic levels of glucose and insulin and the alpha diversity of pregnant women exposed to ABX were higher than those of pregnant women not exposed to ABX.Conclusion Pregnant women are potentially at higher risk of adverse microbial effects. Glucose metabolism and insulin levels were generally higher in pregnant women exposed to ABX than in unexposed women. Also, the composition and color of the gut microbiome changed.All data relevant to the study are included in the article.