RT Journal Article
SR Electronic
T1 Alterations in plantar vessel blood flow in patients with mild diabetic peripheral neuropathy
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e002492
DO 10.1136/bmjdrc-2021-002492
VO 10
IS 1
A1 Qiang Zhou
A1 Zhihui Qian
A1 Maoguang Yang
A1 Jing Liu
A1 Jianan Wu
A1 Luquan Ren
A1 Lei Ren
YR 2022
UL http://drc.bmj.com/content/10/1/e002492.abstract
AB Introduction Early identification and treatment of diabetic peripheral neuropathy (DPN) are crucial. Presently, the mechanism of DPN is not very clear, and there are inconclusive conclusions about the influencing factors of vascular dynamic characteristics in DPN. This study aims to detect and compare the hemodynamic characteristics of plantar blood vessels in patients with mild DPN and healthy participants to explore a simple and reliable new idea and a potential method for early assessment of DPN and to investigate the influence of gender and age on hemodynamic characteristics.Research design and methods Sixty age-matched and gender-matched patients with mild DPN (30 men and 30 women) and 60 healthy participants were randomly recruited. Color Doppler ultrasound was used to measure and analyze the hemodynamic characteristics of plantar-related vessels.Results Ultrasonic measurements had good test–retest reliability. There may be no statistically significant differences in the blood flow velocity and blood flow in the plantar-related blood vessels of participants, irrespective of their gender and age. For patients with mild DPN, color Doppler ultrasound may indicate early hemodynamic abnormalities when there are no obvious abnormalities in the large arteries of the lower limbs, which are specifically manifested as increased blood flow velocity and blood flow in the distal small vessels.Conclusions Our study provides in vivo data support for the dynamic characteristics of the plantar blood vessel biomechanical model and provides a new idea of in vivo and non-invasive early diagnosis of DPN.All data relevant to the study are included in the article or uploaded as supplementary information.