RT Journal Article
SR Electronic
T1 Relationship between serum creatinine to cystatin C ratio and subclinical atherosclerosis in patients with type 2 diabetes
JF BMJ Open Diabetes Research & Care
JO BMJ Open Diab Res Care
FD American Diabetes Association
SP e002910
DO 10.1136/bmjdrc-2022-002910
VO 10
IS 3
A1 Hashimoto, Yoshitaka
A1 Takahashi, Fuyuko
A1 Okamura, Takuro
A1 Osaka, Takafumi
A1 Okada, Hiroshi
A1 Senmaru, Takafumi
A1 Majima, Saori
A1 Ushigome, Emi
A1 Nakanishi, Naoko
A1 Asano, Mai
A1 Hamaguchi, Masahide
A1 Yamazaki, Masahiro
A1 Fukui, Michiaki
YR 2022
UL http://drc.bmj.com/content/10/3/e002910.abstract
AB Introduction Sarcopenia index (SI), calculated by (serum creatinine/cystatin C)×100, is reported to be associated with sarcopenia. Few studies reported the association between SI and subclinical atherosclerosis. We evaluated the association between SI and subclinical atherosclerosis, assessed by brachial-ankle pulse wave velocity (baPWV).Research design and methods One hundred seventy-four patients with type 2 diabetes were included in this cross-sectional study. The relationship between SI and baPWV was assessed by Pearson’s correlation coefficient. To calculate area under the receiver operator characteristic (ROC) curve (AUC) of SI for the presence of subclinical atherosclerosis, which was defined as baPWV >1800 cm/s, ROC analysis was performed. Logistic regression analyses were performed to assess the effect of SI on the prevalence of subclinical atherosclerosis adjusting for covariates.Results Mean age, duration of diabetes, baPWV, and SI were 66.9 (10.1) years, 17.7 (11.6) years, 1802 (372) cm/s, and 77.6 (15.8), respectively. There was an association between SI and baPWV (men; r=−0.25, p=0.001, and women; r=−0.37, p=0.015). The optimal cut-off point of SI for the presence of subclinical atherosclerosis was 77.4 (sensitivity=0.72, specificity=0.58, p<0.001, AUC 0.66 (95% CI: 0.57 to 0.74)). In addition, SI was associated with the prevalence of subclinical atherosclerosis (adjusted OR 0.95, 95% CI: 0.91 to 0.99, p=0.015).Conclusions SI is associated with the prevalence of subclinical atherosclerosis in patients with type 2 diabetes.Data are available on reasonable request.