Table 4

Severe hypoglycemia according to the CES-D score in Japanese patients with type 2 diabetes treated with sulfonylurea and/or insulin

CES-D scorep for trend
Severe hypoglycemia (%)2.4%4.1%5.8%11.1%<0.0001
Multiple logistic regression analysis for severe hypoglycemia*Referent1.64 (0.86 to 2.94)2.09 (0.96 to 4.12)3.66 (1.53 to 7.99)†<0.001
  • Multivariate adjustments include age, sex, duration of diabetes, HbA1c, insulin treatment, self-monitoring of blood glucose, leisure-time physical activity, skipping breakfast, dysesthesia of both feet, ischemic heart disease, and stroke.

  • *Results are reported as ORs (95% CI).

  • †p <0.01 versus referent.

  • CES-D, Center for Epidemiologic Studies Depression Scale; HbA1c, glycated hemoglobin.