Severe hypoglycemia according to the CES-D score in Japanese patients with type 2 diabetes treated with sulfonylurea and/or insulin
| CES-D score | p for trend | ||||
|---|---|---|---|---|---|
| ≤9 | 10–15 | 16–23 | ≥24 | ||
| n | 2141 | 362 | 172 | 81 | |
| Severe hypoglycemia (%) | 2.4% | 4.1% | 5.8% | 11.1% | <0.0001 |
| Multiple logistic regression analysis for severe hypoglycemia* | Referent | 1.64 (0.86 to 2.94) | 2.09 (0.96 to 4.12) | 3.66 (1.53 to 7.99)† | <0.001 |
Multivariate adjustments include age, sex, duration of diabetes, HbA1c, insulin treatment, self-monitoring of blood glucose, leisure-time physical activity, skipping breakfast, dysesthesia of both feet, ischemic heart disease, and stroke.
*Results are reported as ORs (95% CI).
†p <0.01 versus referent.
CES-D, Center for Epidemiologic Studies Depression Scale; HbA1c, glycated hemoglobin.