Table 2

DIAGRAM-derived association results for type 2 diabetes with respect to the loci on interest

Variants previously published for GWAS of any trait
 SNPCHROMOSOMEPOSITIONRISK_ALLELEOTHER_ALLELEP_VALUEOROR_95LOR_95UN_CASESN_CONTROLSGene
 rs790169510114 744 078CT2.50E-651.371.321.4212 17156 862TCF7L2 *
 rs465221744 343 596TC3.20E-041.071.031.11958053 810UBE2Z-GIP-ATP5G1-SNF8
Variants not previously reported by GWAS of type 2 diabetes
 SNPCHROMOSOMEPOSITIONRISK_ALLELEOTHER_ALLELEP_VALUEOROR_95LOR_95UN_CASESN_CONTROLSGene
 rs47804761612 769 508AC4.10E-051.11.051.15663449 797CPPED1
  • These loci survived correction for multiple testing based on the constraints derived from working with the HCT116 ChIP-seq 5 kb gene list and integrating with tag-SNPs coinciding with genes on that list.

  • *Locus previously reported to be associated with type 2 diabetes.

  • ChIP, chromatin immunoprecipitation; SNP, single nucleotide polymorphism.