Binary logistic regression models results for incident T2DM showing the ORs for the univariate and multivariate models
| OR (95% CI) | p Value | ||
|---|---|---|---|
| Univariate binary logistic regression models | |||
| 1-deoxySO | 2.09 (1.22–3.58) | 0.007 | |
| 1-deoxySA | 1.83 (1.12–2.99) | 0.016 | |
| TG | 1.69 (1.05–2.7) | 0.030 | |
| HbA1c | 4.11 (1.42–11.85) | 0.009 | |
| Systolic BP | 1.64 (1.01–2.65) | 0.044 | |
| Potassium | 1.78 (1.05–3.03) | 0.03 | |
| MetS | 2.85 (1.16–7.03) | 0.023 | |
| Multivariate binary logistic regression models | |||
| Model 1 | 1-deoxySO | 2.32 (1.31–4.12) | 0.004 |
| Age | 1.63 (0.99–2.69) | 0.054 | |
| Model 2 | 1-deoxySO | 2.13 (1.23–3.7) | 0.007 |
| Sex | 1.17 (0.46–2.96) | 0.746 | |
| Model 3 | 1-deoxySO | 2.05 (1.2–3.5) | 0.008 |
| BMI | 1.09 (0.68–1.75) | 0.731 | |
| Model 4 | 1-deoxySO | 1.97 (1.13–3.43) | 0.017 |
| MetS | 2.37 (0.93–6.06) | 0.071 | |
| Model 5 | 1-deoxySO | 2.1 (1.22–3.59) | 0.007 |
| Lipid-lowering drugs | 0.85 (0.36–2.04) | 0.720 | |
| Model 6 | 1-deoxySO | 1.76 (0.94–3.27) | 0.076 |
| TG | 1.31 (0.75–2.27) | 0.344 | |
| Model 7 (stepwise logistic regression) | 1-deoxySO | 2.03 (1.19–3.49) | 0.010 |
| Zlog_TG | 0.342 | ||
| Model 8 | 1-deoxySO | 2.1 (1.19–3.71) | 0.010 |
| HbA1c | 4.11 (1.37–12.34) | 0.012 | |
| Model 9 | 1-deoxySO | 2.13 (1.22–3.72) | 0.008 |
| Systolic BP | 1.73 (1.04–2.86) | 0.033 | |
| Model 10 | 1-deoxySO | 1.88 (1.03–3.42) | 0.039 |
| Potassium | 1.62 (0.94–2.78) | 0.083 | |
| Model 1 | 1-deoxySA | 2.0 (1.19–3.36) | 0.009 |
| Age | 1.6 (0.99–2.61) | 0.057 | |
| Model 2 | 1-deoxySA | 1.83 (1.12–3) | 0.017 |
| Sex | 0.93 (0.37–2.29) | 0.869 | |
| Model 3 | 1-deoxySA | 1.82 (1.12–2.97) | 0.016 |
| BMI | 1.13 (0.71–1.8) | 0.607 | |
| Model 4 | 1-deoxySA | 1.68 (1.01–2.79) | 0.048 |
| MetS | 2.26 (0.88–5.79) | 0.088 | |
| Model 5 | 1-deoxySA | 1.83 (1.12–3) | 0.016 |
| Lipid-lowering drugs | 0.88(0.37–2.09) | 0.770 | |
| Model 6 | 1-deoxySA | 1.56 (0.9–2.71) | 0.112 |
| TG | 1.38 (0.81–2.36) | 0.234 | |
| Model 7 (stepwise logistic regression) | 1-deoxySA | 1.81 (1.1–2.96) | 0.019 |
| TG | – | 0.230 | |
| Model 8 | 1-deoxySA | 1.76 (1.06–2.92) | 0.030 |
| HbA1c | 3.78 (1.29–11.13) | 0.016 | |
| Model 9 | 1-deoxySA | 1.76 (1.07–2.89) | 0.025 |
| Systolic BP | 1.57 (0.96–2.56) | 0.071 | |
| Model 10 | 1-deoxySA | 1.62 (0.94–2.77) | 0.082 |
| Potassium | 1.69 (0.99–2.9) | 0.055 | |
Variables are log transformed and standardized in SD units.
ORs are reported per increase of 1 SD unit. Variables in bold font are significant (p<0.05).
BMI, body mass index; BP, blood pressure; HbA1c, glycated Hb; MetS, metabolic syndrome; SA, sphinganine; SO, sphingosine; T2DM, type 2 diabetes mellitus; TG, triglycerides.