Changes in plasma fatty acid composition
| Sitagliptin | p Value* | Mitiglinide | p Value* | p Value† | |||
|---|---|---|---|---|---|---|---|
| Before | After | Before | After | ||||
| C12:0 (lauric acid) | 1.6±1.0 | 2.7±2.2 | 0.011 | 1.7±1.2 | 1.7±0.7 | 0.988 | 0.024 |
| C14:0 (myristic acid) | 23.7±9.8 | 32.3±17.5 | 0.015 | 24.9±12.5 | 26.3±9.2 | 0.586 | 0.083 |
| C16:0 (palmitic acid) | 707.9±182.1 | 779.3±322.1 | 0.212 | 707.4±129.9 | 680.0±125.6 | 0.270 | 0.114 |
| C16:1n-7 (palmitoleic acid) | 71.9±27.5 | 78.4±37.1 | 0.316 | 75.8±37.8 | 72.6±40.1 | 0.521 | 0.233 |
| C18:0 (stearic acid) | 213.0±42.9 | 232.8±86.2 | 0.244 | 204.0±30.3 | 197.9±31.9 | 0.269 | 0.148 |
| C18:1n-9 (oleic acid) | 644.2±245.2 | 747.8±405.7 | 0.151 | 606.9±125.6 | 607.0±142.6 | 0.997 | 0.165 |
| C18:2n-6 (linoleic acid) | 818.7±178.1 | 845.0±279.2 | 0.514 | 781.0±151.6 | 772.4±165.3 | 0.746 | 0.468 |
| C18:3n-6 (γ-linolenic acid) | 10.0±4.7 | 11.6±6.5 | 0.022 | 9.1±4.5 | 9.3±3.8 | 0.805 | 0.159 |
| C18:3n-3 (α-linolenic acid) | 26.1±11.3 | 35.8±26.7 | 0.029 | 23.8±8.6 | 25.1±10.9 | 0.487 | 0.073 |
| C20:0n-6 (arachidic acid) | 7.1±1.4 | 7.5±2.4 | 0.337 | 7.2±1.1 | 6.9±1.1 | 0.083 | 0.145 |
| C20:1n9 (eicosenoic acid) | 5.8±2.5 | 6.8±4.7 | 0.290 | 5.6±2.8 | 5.1±1.1 | 0.329 | 0.163 |
| C20:2n6 (eicosadienoic acid) | 5.9±1.7 | 6.3±2.2 | 0.332 | 5.7±1.3 | 5.6±1.3 | 0.637 | 0.280 |
| C20:3n9 (eicosatrienoic acid) | 2.2±1.2 | 2.6±1.4 | 0.012 | 2.0±1.1 | 1.8±1.0 | 0.436 | 0.027 |
| C20:3n-6 (dihomo-γ-linolenic acid) | 35.8±11.3 | 39.6±14.6 | 0.030 | 37.7±12.2 | 35.7±10.2 | 0.248 | 0.018 |
| C20:4n-6 (arachidonic acid) | 189.0±41.0 | 177.6±53.8 | 0.065 | 178.7±32.1 | 163.7±23.2 | 0.016 | 0.663 |
| C20:5n-3 (eicosapentaenoic acid) | 73.0±30.2 | 70.1±32.2 | 0.579 | 78.8±39.9 | 73.2±42.7 | 0.511 | 0.783 |
| C22:0 (behenic acid) | 18.3±3.7 | 17.9±5.4 | 0.583 | 18.4±4.0 | 17.8±4.7 | 0.269 | 0.836 |
| C22:1n-9 (erucic acid) | 1.5±0.5 | 1.8±0.9 | 0.047 | 1.6±0.6 | 1.8±0.5 | 0.121 | 0.674 |
| C22:4n-6 (docosatetraenoic acid) | 5.0±1.6 | 5.4±2.3 | 0.182 | 4.7±1.4 | 4.6±1.5 | 0.588 | 0.154 |
| C22:5n-3 (docosapentaenoic acid) | 21.1±5.7 | 23.1±9.2 | 0.148 | 21.3±6.9 | 21.5±9.3 | 0.921 | 0.352 |
| C22:6n-3 (docosahexaenoic acid) | 156.0±33.1 | 149.8±37.5 | 0.357 | 163.8±50.1 | 149.2±39.7 | 0.057 | 0.404 |
| C24:1 (nervonic acid) | 34.7±6.2 | 32.0±6.4 | 0.007 | 37.9±7.4 | 36.8±7.7 | 0.297 | 0.250 |
| SCD-16 (C16:1/C16:0) | 0.10±0.03 | 0.10±0.02 | 0.755 | 0.10±0.04 | 0.10±0.04 | 0.971 | 0.840 |
| SCD-18 (C18:1n-9/C18:0) | 2.97±0.61 | 3.12±0.77 | 0.195 | 2.97±0.44 | 3.07±0.53 | 0.151 | 0.685 |
| D6D (C18:3n-6/C18:2n6) | 0.012±0.005 | 0.013±0.007 | 0.023 | 0.012±0.007 | 0.012±0.005 | 0.917 | 0.365 |
| D5D (C20:4n-6/C20:3n6) | 5.70±1.88 | 4.75±1.31 | 0.001 | 5.30±2.24 | 4.90±1.37 | 0.253 | 0.199 |
Data are means±SD.
*p Value for the intragroup comparison (baseline vs 16 weeks).
†p Value for the intergroup comparison (change from baseline between groups).
D5D, Δ5 desaturase.