Mean HbA1c<7.0% | Mean HbA1c≥7.0% | Interaction p | Mean SBP<130 mm Hg | Mean SBP≥130 mm Hg | Interaction p | |||||
---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |||
Events/patients | 37/338 | 44/294 | 37/306 | 44/326 | ||||||
Model 1 | ||||||||||
HbA1cCV (1SD increment) | 1.20 (0.76 to 1.88) | 0.44 | 1.37 (1.00 to 1.87) | 0.052 | 0.99 (0.65 to 1.52) | 0.97 | 1.77 (1.28 to 2.46) | 0.0007 | 0.018 | |
SBPCV (1SD increment) | 1.33 (0.97 to 1.81) | 0.076 | 1.30 (0.89 to 1.88) | 0.18 | 0.79 | 1.59 (1.11 to 2.29) | 0.013 | 1.16 (0.86 to 1.56) | 0.34 | |
Model 2 | ||||||||||
HbA1cVIM (1SD increment) | 1.17 (0.83 to 1.66) | 0.37 | 1.38 (0.99 to 1.93) | 0.054 | 0.96 (0.64 to 1.44) | 0.85 | 1.73 (1.25 to 2.38) | 0.0009 | 0.016 | |
SBPVIM (1SD increment) | 1.32 (0.97 to 1.80) | 0.076 | 1.31 (0.90 to 1.90) | 0.16 | 0.82 | 1.59 (1.12 to 2.28) | 0.011 | 1.19 (0.89 to 1.60) | 0.25 |
All models were adjusted for mean HbA1c, mean SBP, number of visits (ln-transformed), age, sex, diabetes duration, BMI, TC/HDL-C, eGFR, baseline smoking status, baseline alcohol intake, baseline use of insulin, and baseline use of antihypertensive agents.
BMI, body mass index; CV, coefficient of variation; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; SBP, systolic blood pressure; TC, total cholesterol; VIM, variation independent of mean.