Table 2

Measurements of glycometabolic state and cardiovascular risk profile at 4 months

VariableMetformin (n=172)Control (n=174)p Value
Physical diagnostics
 Body weight, mean (95% CI), kg83.8 (83.0 to 84.7)85.2 (84.4 to 86.1)0.024
 Body mass index, mean (95% CI), kg/m226.8 (26.5 to 27.0)27.2 (27.0 to 27.5)0.014
 Systolic blood pressure, mean (95% CI), mmHg123 (120 to 125)125 (122 to 127)0.241
 Diastolic blood pressure, mean (95% CI), mmHg74 (72 to 75)74 (72 to 75)0.649
Laboratory values
 HbA1c, mean (95% CI), %5.83 (5.79 to 5.87)5.89 (5.85 to 5.92)0.049
 HbA1c, mean (95% CI), mmol/mol40.2 (39.8 to 40.6)40.9 (40.4 to 41.2)0.049
 Insulin, mean (95% CI), mU/L22.8 (17.5 to 28.1)18.6 (13.5 to 23.7)0.211
 Total cholesterol, mean (95% CI), mmol/L3.85 (3.73 to 3.97)4.02 (3.90 to 4.14)0.045
 LDL cholesterol, mean (95% CI), mmol/L2.10 (1.99 to 2.20)2.30 (2.20 to 2.40)0.007
 HDL cholesterol, mean (95% CI), mmol/L1.20 (1.16 to 1.23)1.23 (1.20 to 126)0.153
  • Values were calculated using ANCOVA, adjusted for baseline variables.

  • ANCOVA, analysis of covariance; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein.