Table 1

Measures

At regular hospital visits	Body weight, blood pressure (on an outpatient basis) Blood glucose, HbA1c, lipid panel (total cholesterol, LDL cholesterol (non-HDL cholesterol), HDL cholesterol, and triglyceride), hematological examination, hepatic/renal function test, serum electrolytes, and CK
Every 6 months	Urinary albumin–creatinine ratio
Every 12 months	Body height, waist circumference Fasting blood glucose, fasting lipid panel Chest radiograph, echocardiogram, fundus examination Clinical parameters examined centrally hs-CRP, fasting serum insulin, and GA Fundus examination is also performed within 6 months prior to the end of the study
At registration, 1 year later, 3 years later, and at the end of the study	Clinical parameters examined centrally Adiponectin (including high-molecular-weight adiponectin) Questionnaires SF-36, PAID, BDI, PHRF-SCL (SF), and DHQ Adiponectin is examined at registration, in March 2013, and at the end of the study
At the end of the study	DTSQ and recognition testing

BDI, beck depression inventory; DHQ, dietary history questionnaire; DTSQ, diabetes treatment satisfaction questionnaire; GA, glycoalbumin; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; hs-CRP, high-sensitive C reactive protein; LDL, low-density lipoprotein; PAID, problem area in diabetes survey; PHRF-SCL (SF), public health research foundation stress check list (short form), SF-36, medical outcomes study-short-form 36-item health survey.