Sitagliptin | Voglibose | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Parameter | n | Baseline | 12-week | p Value* | n | Baseline | 12-week | p Value* | p Value† | |
Lauric acid | C12:0 (ng/mL) | 118 | 2.3±2.2 | 2.3±2.3 | 0.555 | 120 | 2.5±2.1 | 2.2±2.3 | 0.139 | 0.592 |
Myristic acid | C14:0 (ng/mL) | 118 | 29.9±18.9 | 28.5±19.3 | 0.147 | 120 | 33.1±23.0 | 30.0±22.8 | 0.012 | 0.356 |
Palmitic acid | C16:0 (ng/mL) | 118 | 746.7±259.6 | 709.8±254.1 | 0.019 | 120 | 796.9±268.7 | 747.9±265.4 | 0.001 | 0.494 |
Palmitoleic acid | C16:1ω7 (ng/mL) | 118 | 80.3±46.2 | 77.0±51.6 | 0.130 | 120 | 89.7±51.6 | 82.0±53.7 | 0.000 | 0.049 |
Stearic acid | C18:0 (ng/mL) | 118 | 214.7±53.6 | 212.0±28.7 | 0.532 | 120 | 224.2±57.7 | 218.2±61.8 | 0.033 | 0.291 |
Oleic acid | C18:1ω9 (ng/mL) | 118 | 656.2±236.6 | 653.2±260.1 | 0.799 | 120 | 714.9±295.4 | 671.7±268.3 | 0.049 | 0.194 |
Linoleic acid | C18:2ω6 (ng/mL) | 118 | 774.4±182.1 | 736.3±188.6 | 0.021 | 120 | 798.6±208.2 | 807.2±244.4 | 0.902 | 0.143 |
γ-linolenic acid | C18:3ω6 (ng/mL) | 118 | 11.4±6.5 | 10.8±6.0 | 0.941 | 120 | 11.9±6.9 | 10.2±5.5 | 0.000 | 0.023 |
α-Linolenic acid | C18:3ω3 (ng/mL) | 118 | 27.6±12.5 | 25.9±11.1 | 0.010 | 120 | 27.3±15.0 | 27.2±16.3 | 0.331 | 0.164 |
Arachidic acid | C20:0 (ng/mL) | 118 | 7.2±1.3 | 7.3±1.6 | 0.876 | 120 | 7.6±1.6 | 7.7±1.7 | 0.935 | 0.935 |
Eicosenoic acid | C20:1ω9 (ng/mL) | 118 | 5.5±2.0 | 5.3±2.2 | 0.562 | 120 | 6.1±6.8 | 6.3±6.9 | 0.306 | 0.274 |
Eicosadienoic acid | C20:2ω6 (ng/mL) | 118 | 5.9±1.8 | 5.9±2.0 | 0.599 | 120 | 6.3±2.0 | 6.3±21 | 0.764 | 0.929 |
5-8-11Eicosatrienoic acid | C20:3ω9 (ng/mL) | 118 | 2.2±1.4 | 2.2±1.6 | 0.549 | 120 | 2.8±2.6 | 2.5±2.4 | 0.008 | 0.116 |
Dihomo-γ-linolenic acid | C20:3ω6 (ng/mL) | 118 | 38.8±13.2 | 39.7±16.4 | 0.260 | 120 | 42.4±15.5 | 39.9±12.7 | 0.005 | 0.010 |
Arachidonic acid | C20:4ω6 (ng/mL) | 118 | 173.2±48.7 | 172.0±51.3 | 0.706 | 120 | 184.5±46.5 | 183.5±44.6 | 0.691 | 0.898 |
Eicosapentaenoic acid | C20:5ω3 (ng/mL) | 118 | 80.6±48.3 | 79.7±43.5 | 0.884 | 120 | 81.2±70.0 | 85.5±78.4 | 0.659 | 0.955 |
Behenic acid | C22:0 (ng/mL) | 118 | 17.9±3.3 | 17.9±3.6 | 0.838 | 120 | 32.1±3.7 | 19.1±4.3 | 0.465 | 0.651 |
Erucic acid | C22:1ω9 (ng/mL) | 118 | 1.6±0.8 | 1.6±0.7 | 0.613 | 120 | 1.8±0.9 | 1.7±0.9 | 0.768 | 0.291 |
Docosatetraenoic acid | C22:4ω6 (ng/mL) | 118 | 5.2±2.2 | 5.1±2.6 | 0.248 | 120 | 5.5±2.3 | 5.1±1.9 | 0.011 | 0.306 |
Docosapentaenoic acid | C22:5ω3 (ng/mL) | 118 | 25.2±10.0 | 24.3±9.4 | 0.399 | 120 | 25.8±13.1 | 24.0±13.5 | 0.004 | 0.955 |
Lignoceric acid | C24:0 (ng/mL) | 118 | 16.3±2.8 | 16.3±3.3 | 0.775 | 120 | 17.5±3.4 | 17.8±3.9 | 0.423 | 0.598 |
Docosahexaenoic acid | C22:6ω3 (ng/mL) | 118 | 175.2±65.3 | 169.5±58.7 | 0.305 | 120 | 175.2±94.5 | 167.7±96.1 | 0.095 | 0.531 |
Nervonic acid | C24:1ω9 (ng/mL) | 118 | 34.8±7.5 | 34.5±7.5 | 0.357 | 120 | 37.0±8.2 | 37.7±8.0 | 0.028 | 0.028 |
EPA+DHA | (ng/mL) | 118 | 255.9±107.5 | 249.2±92.6 | 0.536 | 120 | 256.3±160.3 | 253.1±169.4 | 0.436 | 0.782 |
EPA/AA ratio | 118 | 0.49±0.31 | 0.49±0.30 | 0.705 | 120 | 0.44±0.32 | 0.044±0.32 | 0.435 | 0.895 | |
Total ω3 fatty acids | (ng/mL) | 118 | 308.7±121.9 | 299.0±105.3 | 0.370 | 120 | 309.4±181.0 | 304.3±191.6 | 0.308 | 0.735 |
Total ω6 fatty acids | (ng/mL) | 118 | 1008.7±224.8 | 969.8±237.7 | 0.024 | 120 | 1049.2±238.2 | 1052.3±273.9 | 0.684 | 0.239 |
Total ω9 fatty acids | (ng/mL) | 118 | 700.2±239.2 | 696.8±263.6 | 0.794 | 120 | 762.6±300.8 | 720.0±272.5 | 0.053 | 0.210 |
ω3/ω6 ratio | 118 | 0.32±0.13 | 0.32±0.11 | 0.236 | 120 | 0.30±0.14 | 0.30±0.14 | 0.409 | 0.151 | |
Total saturated fatty acids | (ng/mL) | 118 | 1034.9±330.7 | 994.1±330.3 | 0.050 | 120 | 1101.1±346.5 | 1043.0±348.1 | 0.002 | 0.515 |
Monounsaturated fatty acids | (ng/mL) | 118 | 778.3±276.8 | 771.7±305.2 | 0.762 | 120 | 854.3±346.8 | 799.5±306.6 | 0.020 | 0.132 |
Polyunsaturated fatty acids | (ng/mL) | 118 | 1319.5±277.3 | 1270.9±289.2 | 0.014 | 120 | 1361.4±336.2 | 1359.0±384.4 | 0.562 | 0.233 |
δ-5desaturase (20:4 ω6/20:3 ω6) | 118 | 4.73±1.42 | 4.72±1.62 | 0.595 | 120 | 4.78±1.77 | 4.97±1.64 | 0.014 | 0.031 | |
δ-6desaturase (18:3 ω6/18:2 ω6) | 118 | 0.015±0.008 | 0.015±0.007 | 0.321 | 120 | 0.016±0.01 | 0.014±0.009 | 0.009 | 0.007 |
Data are expressed as means±SD.
*p Value for the intragroup comparison (baseline vs 12 weeks).
†p Value for the intergroup comparison (difference in changes from baseline between groups).
AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid.