Changes in the characteristics of patients between baseline and 12 weeks
| Sitagliptin | Voglibose | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | n | Baseline | 12-week | p Value* | n | Baseline | 12-week | p Value* | p Value† |
| Body weight (kg) | 120 | 63.8±13.6 | 63.7±13.3 | 0.842 | 120 | 65.8±15.2 | 65.3±15.1 | 0.025 | 0.126 |
| BMI | 118 | 24.9±4.5 | 24.9±4.4 | 0.777 | 119 | 25.1±4.5 | 24.9±4.4 | 0.024 | 0.086 |
| Waist (cm) | 116 | 88.7±10.5 | 88.2±10.0 | 0.195 | 120 | 91.0±11.7 | 90.0±11.1 | 0.013 | 0.363 |
| SBP (mm Hg) | 120 | 130.0±16.8 | 129.5±17.1 | 0.998 | 121 | 131.6±18.5 | 128.9±16.7 | 0.067 | 0.265 |
| DBP (mm Hg) | 120 | 76.0±12.1 | 75.4±12.1 | 0.576 | 121 | 75.1±12.9 | 74.4±12.5 | 0.689 | 0.918 |
| WBC (/mm3) | 120 | 5815±1362 | 6057±1590 | 0.050 | 119 | 5985±1762 | 5940±1975 | 0.315 | 0.037 |
| Neutrophils (/mm3) | 108 | 3279±1015 | 3570±1096 | 0.008 | 107 | 3485±1313 | 3431±1587 | 0.193 | 0.007 |
| Eosinophils (/mm3) | 105 | 156±120 | 151±120 | 0.000 | 105 | 163±108 | 164±114 | 0.821 | 0.074 |
| Basophils (/mm3) | 105 | 30±23 | 31±23 | 0.359 | 105 | 32±21 | 34±28 | 0.864 | 0.247 |
| Lymphocytes (/mm3) | 105 | 1951±607 | 1866±586 | 0.007 | 105 | 2041±723 | 2023±766 | 0.772 | 0.023 |
| Monocytes (/mm3) | 105 | 323±113 | 345±122 | 0.004 | 105 | 339±139 | 340±150 | 0.270 | 0.009 |
| PLT (104/mm3) | 120 | 21.0±5.5 | 20.8±5.6 | 0.281 | 119 | 21.8±6.0 | 21.3±5.8 | 0.084 | 0.574 |
| RBC (103/mm3) | 120 | 458.4±43.7 | 459.2±45.4 | 0.723 | 119 | 454.1±52.1 | 457.2±50.3 | 0.124 | 0.612 |
| Hb (g/mL) | 120 | 13.9±1.6 | 14.0±1.8 | 0.943 | 119 | 13.9±1.6 | 14.0±1.5 | 0.548 | 0.882 |
| Ht (%) | 120 | 41.6±4.1 | 41.7±4.4 | 0.565 | 119 | 41.3±4.2 | 41.8±4.0 | 0.030 | 0.399 |
| AST (IU/L) | 120 | 26±13 | 26±13 | 0.554 | 120 | 26±16 | 25±11 | 0.961 | 0.776 |
| ALT (IU/L) | 120 | 32±25 | 30±21 | 0.459 | 120 | 30±26 | 30±20 | 0.505 | 0.309 |
| ALP (IU/L) | 120 | 236±71 | 226±76 | 0.000 | 118 | 237±91 | 236±101 | 0.168 | 0.074 |
| BAP (μg /L) | 116 | 12.6±5.6 | 12.3±5.6 | 0.140 | 116 | 12.7±5.5 | 12.5±4.9 | 0.832 | 0.186 |
| γ-GTP (IU/L) | 120 | 44±50 | 49.2±87.6 | 0.836 | 119 | 49±57 | 47±51 | 0.011 | 0.051 |
| CK (IU/L) | 117 | 105.5±71.6 | 105.2±68.0 | 0.920 | 116 | 109.2±59.5 | 107.4±54.5 | 0.552 | 0.720 |
| BUN (mg/dL) | 120 | 14.9±4.1 | 15.0±4.6 | 0.838 | 120 | 15.3±4.9 | 14.5±4.9 | 0.041 | 0.166 |
| Cr (mg/dL) | 120 | 0.71±0.19 | 0.74±0.19 | 0.000 | 120 | 0.74±0.27 | 0.76±0.27 | 0.129 | 0.199 |
| UA (mg/dL) | 119 | 5.08±1.14 | 5.30±1.24 | 0.001 | 120 | 5.13±1.40 | 5.28±1.40 | 0.073 | 0.328 |
| Cystatin C (mg/L) | 114 | 0.82±0.18 | 0.85±0.19 | 0.001 | 112 | 0.86±0.23 | 0.86±0.23 | 0.177 | 0.087 |
| eGFRcreat (mL/min/1.73 m2) | 120 | 85.0±28.4 | 80.6±26.5 | 0.000 | 120 | 80.4±24.1 | 78.3±23.4 | 0.069 | 0.203 |
| eGFRcys (mL/min/1.73 m2) | 114 | 91.1±23.2 | 91.1±29.3 | 0.969 | 112 | 87.9±25.0 | 88.5±22.9 | 0.626 | 0.132 |
| eGFRaverage (mL/min/1.73 m2) | 114 | 88.0±23.3 | 85.6±24.6 | 0.006 | 111 | 83.7±22.2 | 83.4±20.8 | 0.687 | 0.053 |
| TC (mg/dL) | 120 | 185.1±33.4 | 184.9±39.0 | 0.910 | 118 | 191.6±32.4 | 193.6±40.8 | 0.066 | 0.272 |
| HDL-C (mg /dL) | 118 | 52.7±15.4 | 52.3±14.8 | 0.873 | 118 | 54.9±18.0 | 54.8±18.3 | 0.739 | 0.712 |
| Triglyceride (mg/dL) | 120 | 136.0±83.1 | 129.8±85.5 | 0.098 | 120 | 144.2±103.2 | 129.3±79.0 | 0.015 | 0.450 |
| LDL-C (mg/dL) | 118 | 104.9±29.6 | 106.5±34.1 | 0.499 | 117 | 107.5±26.5 | 112.7±36.5 | 0.001 | 0.026 |
| sdLDL (mg/dL) | 118 | 36.8±15.4 | 34.9±15.1 | 0.134 | 120 | 38.0±16.6 | 38.3±17.6 | 0.831 | 0.220 |
| IRI (IU/L) | 116 | 8.46±8.20 | 8.69±9.37 | 0.342 | 118 | 14.1±65.1 | 14.2±69.5 | 0.028 | 0.039 |
| CPR (ng/mL) | 118 | 2.10±0.88 | 2.04±0.84 | 0.421 | 120 | 2.08±1.03 | 2.05±1.13 | 0.634 | 0.715 |
| HMW adiponectin (μg/dL) | 118 | 3.17±2.30 | 3.50±2.57 | 0.000 | 120 | 3.53±3.65 | 3.74±3.53 | 0.000 | 0.161 |
| Hypersensitive TNF-α (pg/mL) | 118 | 3.11±12.47 | 2.23±5.21 | 0.079 | 120 | 1.42±1.87 | 1.55±1.83 | 0.000 | 0.538 |
| Leptin (ng/mL) | 118 | 8.26±6.90 | 8.27±7.17 | 0.561 | 120 | 9.02±9.28 | 8.21±6.59 | 0.694 | 0.540 |
| HOMA-IR | 115 | 3.30±3.44 | 2.98±3.02 | 0.056 | 117 | 5.21±23.02 | 5.52±29.02 | 0.003 | 0.443 |
| HOMA-β | 115 | 36.0±32.8 | 47.2±57.6 | 0.000 | 117 | 63.7±299.6 | 59.5±237.4 | 0.408 | 0.002 |
| SUIT index | 117 | 39.5±30.4 | 45.9±28.3 | 0.000 | 118 | 38.0±22.1 | 40.9±23.8 | 0.004 | 0.047 |
| CPI | 117 | 1.41±0.67 | 1.52±0.71 | 0.001 | 118 | 1.38±0.68 | 1.43±0.78 | 0.080 | 0.207 |
| QUICKI | 112 | 0.34±0.04 | 0.34±0.04 | 0.093 | 116 | 0.34±0.05 | 0.34±0.05 | 0.090 | 0.784 |
| Proinsulin (pM) | 112 | 26.9±17.2 | 22.5±14.3 | 0.000 | 104 | 26.5±17.9 | 25.3±17.4 | 0.036 | 0.328 |
| Proinsulin/Insulin Ratio | 101 | 0.70±0.67 | 0.54±0.33 | 0.000 | 91 | 0.63±0.39 | 0.65±0.49 | 0.698 | 0.015 |
| HbA1c (%) | 120 | 7.94±1.03 | 7.15±0.88 | 0.000 | 121 | 7.86±0.78 | 7.56±1.02 | 0.000 | 0.000 |
| 1,5AG (μg/mL) | 109 | 6.45±4.16 | 10.55±5.96 | 0.000 | 105 | 7.43±5.29 | 12.6±8.12 | 0.000 | 0.047 |
| FPG (mg/dL) | 119 | 156.3±35.1 | 140.0±31.7 | 0.000 | 119 | 153.2±35.2 | 148.0±43.0 | 0.001 | 0.006 |
Data are expressed as means±SD.
*p Value for the intragroup comparison (baseline vs 12 weeks).
†p Value for the intergroup comparison (difference in changes from baseline between groups).
ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; BAP, bone alkaline phosphatase; BMI, body mass index; BUN, blood urea nitrogen; CK, creatinine kinase; CPI, CPR index; CPR, C-peptide immunoreactivity; Cr, creatinine; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; Hb, hemoglobin; HDL-c, low-density lipoprotein cholesterol; HMW, high molecular weight; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-β, homeostasis model assessment-β; IRI, fasting serum insulin; LDL-C, low-density lipoprotein-cholesterol; PLT, platelet; QUICKI, quantitative insulin sensitivity check index; RBC, red blood cell; SBP, systolic blood pressure; sdLDL, small dense low-density lipoprotein; SUIT, secretory unit of islet in transplantation index; TC, total cholesterol; TNF-α, tumour necrosis factor α; UA, uric acid; WBC, white blood cell count.