Table 3

Factors associated with a change in HbA1c

SitagliptinVoglibose
rsp Valuersp Value
Baseline
Body weight (kg)−0.0510.577−0.0820.374
Body mass index−0.1420.126−0.080.390
Fasting plasma glucose (mg/dL)−0.1130.2220.1070.246
1,5 AG (%)0.3380.000−0.0340.714
HbA1c (%)−0.5890.000−0.1210.185
Total cholesterol (mg/dL)0.0500.5880.0090.948
Fasting serum insulin (IU/L)−0.0920.328−0.0790.392
CPR (ng/mL)−0.1010.275−0.0040.965
HMW adiponectin (µg/mL)0.2230.0150.1370.137
CPI−0.0480.609−0.0380.684
HOMAIR−0.1280.1710.1140.222
HOMA-β−0.0160.8610.0330.722
EPA (ng/mL)−0.0640.4900.0620.502
DHA (ng/mL)−0.0770.118−0.0780.396
Change from baseline
 ΔFPG0.3860.0000.4210.000
 ΔBW0.2120.0200.0470.609
 ΔBMI0.2060.0250.0580.533
 ΔALP0.2690.0030.1870.042
 ΔTC0.2310.011−0.0620.502
 ΔLDLC0.2660.0040.1510.103
 ΔTG0.0840.362−0.1520.098
 ΔHMW adiponectin−0.3100.001−0.3460.000
 ΔHOMA-IR0.2330.0120.1050.262
 ΔHOMA-β−0.3040.001−0.2220.016
 ΔSUIT index−0.3770.000−0.2610.004
 ΔQUICKI−0.1850.047−0.1750.060
 ΔCPI−0.2350.011−0.1560.091
 ΔProinsulin insulin ratio0.1990.0460.1770.094
 ΔEPA−0.0100.914−0.0620.502
 ΔDHA0.0730.430−0.0650.482
  • AG, anhydroglucitol; ALP, alkaline phosphatase; BMI, body mass index; BW, body weight; CPR, C-peptide immunoreactivity; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FPG, fasting plasma glucose; HbA1c, hemoglobin A1c; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-β, homeostasis model assessment-β; HMW, high molecular weight; LDLC, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride.