Table 1a

Clinical and convenience attributes related to insulin treatment; Table 1b Typical scenario choice sets for WTP

1a Core attributes	Levels for each attribute
Change in HbA_1c	▸ 1%-point reduction in HbA_1c ▸ No change
Number of minor hypoglycemic events	▸ 52 per year ▸ 12 per year ▸ 4 per year ▸ 0 per year
Number of major hypoglycemic events (per 12 months)	▸ 1 per year ▸ 0 per year
Preparation of insulin (rolling and inverting the pen or vial)	▸ Preparation of insulin ▸ No preparation of insulin
Number of injections per day	▸ 1 injection per day ▸ 2 injections per day ▸ 4 injections per day
Change in weight	▸ Weight increase of 1 kg ▸ Remain the same weight ▸ Weight decrease of 3 kg ▸ Weight decrease of 5 kg
Payment per month (out-of-pocket expense)	▸ US$27.75 ▸ US$61.05 ▸ US$127.65 ▸ US$277.50

1b Typical WTP scenario choice sets
	Treatment A	Treatment B
HbA_1c levels	No change	Reduction of 1%
Number of minor hypos	0 yearly	52 yearly
Number of major hypos	1 yearly	0 yearly
Weight change	No change	Lose 3 kg
Preparation of insulin before injection (rolling and inverting the pen or vial)	No	Yes
Number of insulin injections	1 daily injection	4 daily injections
Payment per month (out-of-pocket	US$277.50	US$61.05
Which treatment do you prefer?