Diabetes and impaired fasting glucose in 721 HEIRS Study participants*
| Classification | HFE p.C282Y/p.C282Y (n=245) | HFE wt/wt (n=476) | p Value | OR (95% CI) | Cohen's h statistic |
|---|---|---|---|---|---|
| Diagnosed diabetes, percent (n) | 9.0 (5.8 to 13.5) (22) | 5.7 (3.8 to 8.3) (27) | 0.1644 | 1.6 (0.9 to 2.9); p=0.0974 | 0.13 |
| Undiagnosed diabetes, percent (n) | 3.7 (1.8 to 7.1) (9) | 4.0 (2.5 to 6.3) (19) | 1.0000 | 0.9 (0.4 to 2.1); p=0.8342 | 0.02 |
| Impaired fasting glucose, percent (n) | 21.6 (16.8 to 27.4) (53) | 24.2 (20.4 to 28.3) (115) | 0.4587 | 0.9 (0.6 to 1.3); p=0.4473 | 0.06 |
*Proportions were compared using Fisher's exact test (two-tailed). Proportions are displayed as percentage (95% confidence limits; n). Observations on 721 participants include 672 participants from the present report and 49 HEIRS Study clinical examination participants with diagnosed diabetes described in a previous report (22). Overall prevalences in 721 participants: diagnosed diabetes 6.5% (4.9% to 8.5%); undiagnosed diabetes 3.9% (2.6% to 5.6%); and impaired fasting glucose 23.3% (20.3% to 26.6%).
HEIRS, Hemochromatosis and Iron Overload Screening.