Baseline variables associated with weight change from baseline in patients started on basal insulin
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Covariate | Regression coefficient (95% CI) | p Value | Regression coefficient (95% CI) | p Value |
| Baseline weight (kg) | 0.93 (0.87 to 0.99) | <0.001* | 0.89 (0.81 to 0.97) | <0.001 |
| Age (years) | −0.06 (−0.17 to 0.05) | 0.28 | ||
| Gender (female) | −2.03 (−4.8 to 0.8) | 0.156* | −0.95 (−4.92 to 3.02) | 0.64 |
| Height (cm) | 0.18 (0.01 to 0.35) | 0.04* | 0.15 (−0.09 to 0.39) | 0.21 |
| Diabetes duration (years) | 2.28 (−0.35 to 4.21) | 0.02* | 2.52 (0.53 to 4.52) | 0.01 |
| HbA1c (%) | 0.24 (−0.39 to 0.86) | 0.45 | ||
| FPG (mmol/L) | −0.41 (−1.08 to 0.25) | 0.22 | ||
| PPG (mmol/L) | 0.22 (−0.13 to 0.57) | 0.21 | ||
| Prior MIC | −0.85 (−4.25 to 2.55) | 0.62 | ||
| Prior MAC | 0.90 (−2.80 to 4.59) | 0.63 | ||
| Smoking | 0.61 (−2.55 to 3.76) | 0.70 | ||
| β-blockers | −2.20 (−6.46 to 2.07) | 0.31 | ||
| Metformin | −2.18 (−5.08 to 0.71) | 0.14* | −1.17 (−4.10 to 1.75) | 0.43 |
| Sulfonylureas | −0.71 (−5.90 to 4.48) | 0.79 | ||
| DPP-4 inhibitors | −2.43 (−8.96 to 4.09) | 0.46 | ||
| Other BG-lowering drugs | −1.81 (−6.99 to 3.36) | 0.49 | ||
| Combinations | 1.46 (−4.42 to 7.34) | 0.62 | ||
Bold indicates significance. Univariate ANCOVA additionally included baseline weight as predictor. Multivariate ANCOVA accounted for all covariates with*.
ANCOVA, analysis of covariance; BG, blood glucose; DPP-4, dipeptidyl peptidase-4; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; MAC, macrovascular disease; MIC, microvascular disease; PPG, postprandial glucose.