Table 1

Baseline clinical and biochemical characteristics

n20 (Switch)5 (Addition)
Age (years)67.6±9.071.2±4.6
BMI (kg/m2)25.1±4.026.6±3.3
BP (mm Hg)130.9±12.3/71.8±10.8145.4±18.5/73.0±6.8
HbA1c (%)7.3±0.97.8±0.9
FPG (mg/dL)153.7±38.5182.8±80.5
LDL-C (mg/dL)91.5±25.4104.2±17.6
HDL-C (mg/dL)50.2±13.946.8±11.0
TG (mg/dL)165.6±98.7123.2±46.6
ALT (IU/L)20.3±9.821.0±6.4
UA (mg/dL)5.5±1.34.6±1.3
eGFR (mL/min/1.73 m2)74.0±18.466.3±23.9
eGFR>90(mL/min/1.73 m2), n (%)5 (25)1 (20)
eGFR 60–90 (mL/min/1.73 m2), n (%)10 (50)2 (40)
eGFR 30–60 (mL/min/1.73 m2), n (%)5 (25)2 (40)
Cystatin C (mg/dL)0.95±0.230.98±0.35
UACR (mg/g Cr)206.4±343.9172.3±139.4
UACR 30–300 (mg/g Cr), n (%)16 (80)4 (80)
UACR>300 (mg/g Cr), n (%)4 (20)1 (20)
UACR (log) (mg/g Cr)1.95±0.511.99±0.38
ULFABP>5.0 (μg/g Cr), n (%)8 (40)3 (60)
ULFABP (μg/g Cr)8.5±2.86.4±0.95
Duration of diabetes (years)15.1±7.612.4±4.8
  • Data are the mean±SD, or n (%).

  • ALT, alanine transaminase; BMI, body mass index; BP, blood pressure; Cr, creatinine; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; Hb1Ac, hemoglobin A1c; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; TG, triglyceride; UA, uric acid; UACR, urinary albumin to creatinine ratio; ULFABP, urinary liver-type fatty acid-binding protein to creatinine ratio.