Table 1

Baseline clinical and biochemical characteristics of study subjects by obesity and insulin sensitivity status

CharacteristicIROISOp ValueIRNISNp Value
Number769617131
Gender (F/M)58/1870/260.649/891/400.17
Ethnicity (AA/EA)51/2558/380.398/972/590.54
Age (year)44.0±12.144.0±10.60.9742.5±7.0046.2±9.420.11
BMI (kg/m2)36.7±6.8635.1±5.260.0426.4±2.2324.2±2.890.003
HOMA-IR3.51±1.601.49±0.83<0.00013.35±1.581.09±0.10<0.0001
Si-clamp0.058±0.0250.138±0.048<0.00010.065±0.0190.176±0.056<0.0001
FPG (mg/dL)93.3±6.4792.7±7.570.6093.6±5.7890.7±6.290.08
2hrPG (mg/dL)128±27.2125±24.20.42129±23.8121±26.80.19
HbA1c (%)5.59±0.565.64±0.440.245.58±0.425.51±0.400.22
Food habits score2.64±0.502.57±0.440.362.70±0.462.54±0.550.26
Physical activity (Met-hour/week)18.0±42.213.8±19.60.4313.7±21.322.5±35.10.32
  • To convert the values for glucose to millimoles per liter, multiply by 0.0555.

  • 2hrPG, 2-hour plasma glucose during 75 g oral glucose tolerance test; AA, African American; EA, European American; FPG, fasting plasma glucose; HbA1c, hemoglobin A1c; HOMA-IR, homeostasis model of insulin resistance; IRN, insulin-resistant non-obese; IRO, insulin-resistant obese; ISN, insulin-sensitive non-obese; ISO, insulin-sensitive obese; Si-clamp, insulin sensitivity by hyperinsulinemic euglycemic clamp expressed as µmol/kg fat-free mass/min/pmol/L .