Primary and secondary outcomes
| One-bag system Mean (±SD) | Two-bag system Mean (±SD) | p Value | |
| Primary outcome | |||
| Time to close anion gap (hours) | 13.57 (±1.75) | 10.95 (±1.63) | <0.01 |
| Secondary outcomes | |||
| Time to reach plasma glucose<250 mg/dL (hours) | 9.15 (±1.38) | 7.82 (±1.28) | 0.02 |
| Time to reach serum HCO3>18 mmol/L (hours) | 19.95 (±1.99) | 18.50 (±2.28) | 0.36 |
| Hospital length of stay (days) | 4.86 (±3.63) | 4.33 (±2.53) | 0.09 |
| % | % | ||
| Hypoglycemia (BS<70 mg/dL) | 8.43 | 1.49 | <0.01 |
↵Outcome measures comparing the one-bag versus two-bag protocols used the two independent samples t-test. For details, see online supplementary appendix 2.