Table 5

Adjusted HRs for all-cause, cardiovascular (CV) and non-CV mortality in each of the stratified analyses

Strata (category A, category B)Category A
HR (95% CI)
Category B
HR (95% CI)
P value for interaction test
CV mortality
 Duration of treated diabetes (<4, ≥4)0.59 (0.51 to 0.69)0.54 (0.48 to 0.60)0.687
 Use of other thiazolidinediones (never, ever)0.56 (0.51 to 0.62)0.72 (0.55 to 0.94)0.111
 History of diabetic complications (no, yes)0.52 (0.45 to 0.59)0.63 (0.54 to 0.72)0.002
 History of macrovascular disease (no, yes)0.50 (0.42 to 0.58)0.63 (0.56 to 0.71)<0.001
 History of chronic kidney disease or renal impairment (no, yes)0.52 (0.47 to 0.58)0.72 (0.60 to 0.87)0.008
Non-CV mortality
 Duration of treated diabetes (<4, ≥4)0.64 (0.57 to 0.72)0.63 (0.56 to 0.70)0.339
 Use of other thiazolidinediones (never, ever)0.60 (0.55 to 0.65)0.86 (0.69 to 1.08)0.004
 History of diabetic complications (no, yes)0.57 (0.51 to 0.63)0.69 (0.61 to 0.78)0.004
 History of macrovascular disease (no, yes)0.58 (0.52 to 0.64)0.70 (0.62 to 0.80)<0.001
 History of chronic kidney disease or renal impairment (no, yes)0.58 (0.52 to 0.63)0.75 (0.64 to 0.89)0.013
All-cause mortality
 Duration of treated diabetes (<4, ≥4)0.62 (0.56 to 0.68)0.58 (0.53 to 0.63)0.836
 Use of other thiazolidinediones (never, ever)0.58 (0.54 to 0.62)0.80 (0.67 to 0.95)0.001
 History of diabetic complications (no, yes)0.54 (0.5 to 0.59)0.66 (0.60 to 0.72)<0.001
 History of macrovascular disease (no, yes)0.55 (0.5 to 0.6)0.66 (0.61 to 0.72)<0.001
 History of chronic kidney disease or renal impairment (no, yes)0.55 (0.51 to 0.59)0.74 (0.65 to 0.84)<0.001