Table 3

Multivariable†HR for dysglycemia and diabetes according to serum creatinine categories among subjects with normal glucose levels at baseline

Serum creatinine (mg/dL)
0.38–0.690.70–0.790.80–0.890.90–1.10TotalP for trend
Total subjects at risk31395210647173046
No. of subjects with dysglycemia78187188143596
Age-adjusted HR (95% CI)1.5 (1.1 to 1.9)**1.1 (0.9 to 1.3)1.0 (0.8 to 1.2)1.000.02
Multivariable HR (95% CI)1.5 (1.1 to 1.9)**1.1 (0.9 to 1.4)1.0 (0.8 to 1.3)1.000.01
Age <43 yearsCases/subjects38/18078/51484/58753/356253/1637
Multivariable HR (95% CI)1.8 (1.2 to 2.8)**1.3 (0.9 to 1.8)1.2 (0.8 to 1.7)1.00<0.01
Age ≥43 yearsCases/subjects40/133109/438104/47790/361343/1409
Multivariable HR (95% CI)1.3 (0.9 to 1.9)1.1 (0.8 to 1.5)0.9 (0.7 to 1.2)1.000.20
BMI <25 kg/m2Cases/subjects49/224106/693118/73878/453351/2108
Multivariable HR (95% CI)1.5 (1.0 to 2.2)*1.0 (0.7 to 1.3)1.0 (0.8 to 1.4)1.000.09
BMI ≥25 kg/m2Cases/subjects29/8981/25970/32665/264245/938
Multivariable HR (95% CI)1.5 (0.9 to 2.3)1.4 (1.0 to 2.0)1.0 (0.7 to 1.4)1.000.04
With family history of diabetesCases/subjects56/244156/824156/925114/611482/2604
Multivariable‡ HR (95% CI)0.9 (0.5 to 1.6)0.9 (0.5 to 1.4)0.8 (0.5 to 1.3)1.000.61
Without family history of diabetesCases/subjects22/6931/12832/13929/106114/442
Multivariable‡ HR (95% CI)1.6 (1.2 to 2.3)**1.3 (1.0 to 1.6)1.1 (0.9–1.4)1.00<0.01
With high physical activityCases/subjects57/203109/618115/65087/392368/1863
Multivariable§ HR (95% CI)1.4 (0.8 to 2.3)1.7 (1.2 to 2.4)**1.2 (0.9 to 1.7)1.000.05
Without high physical activityCases/subjects21/11098/33473/41456/325228/1,183
Multivariable§ HR (95% CI)1.6 (1.1–2.2)*0.9 (0.7 to 1.2)0.9 (0.7 to 1.2)1.00<0.01