Table 2

Diagnostic measure of test instruments using 2-hour OGTT (≥8.5 mmol/L or ≥7.8 mmol/L) and fasting plasma glucose (≥5.1 mmol/L or ≥5.6 mmol/L) as diagnostic criteria

Reference testDiagnostic measureTPFNFPTNSensitivity(%)Specificity (%)PPV (%)NPV (%)Accuracy (%)DOR
2-hour OGTT ≥8.5 mmol/L*Risk factors19169726754.373.416.494.471.73.3
Glycosuria138133832.696.77.191.088.30.8
RBG5331638113.296.023.892.088.73.6
HbA1c137263642.693.33.790.885.30.4
FPG*26127731868.480.525.296.479.59.0
FPG†16212936743.292.735.694.688.59.6
1-hour OGTT1523539139.598.775.094.493.651.0
2-hour OGTT ≥7.8 mmol/L†Risk factors23359324839.772.719.887.667.91.8
Glycosuria359113624.897.121.486.083.91.7
RBG656153589.796.028.686.583.72.6
HbA1c259253423.393.27.485.380.40.5
FPG*38226530863.382.636.990.979.98.2
FPG†21392434935.093.646.790.085.57.8
1-hour OGTT1744337027.899.285.089.489.247.7
FPG ≥5.1 mmol/L*Risk factors31678321731.672.327.276.462.31.2
Glycosuria510193304.797.335.776.675.31.8
RBG11951032910.497.152.477.672.23.8
HbA1c1093183179.794.635.777.370.31.9
1-hour OGTT1789333416.099.185.079.075.221.3
2-hour OGTT*27761231826.296.469.280.779.79.4
2-hour OGTT†38652230836.993.363.382.679.98.2
FPG ≥5.6 mmol/L†Risk factors18279826540.073.015.590.869.41.8
Glycosuria444103878.397.528.689.887.93.5
RBG8401338416.796.738.190.688.15.9
HbA1c6412236912.894.421.490.085.62.5
1-hour OGTT1335738827.198.265.091.790.520.6
2-hour OGTT*17282136737.894.644.792.988.710.6
2-hour OGTT†21243934946.789.935.093.685.57.8
  • Screen-positive is ≥1 risk factors, trace/above reagent-strip glycosuria and random capillary blood glucose >7.0mmol/L. Diagnostic-positive is HbA1c ≥6.5%†, fasting venous plasma glucose ≥5.1mmol/L* and ≥5.6mmol/L†, and 1-hour OGTT ≥10.0mmol/L* and 2-hour OGTT ≥8.5mmol/L* and ≥7.8mmol/L† per the *WHO and †NICE criteria. Higher sensitivity, specificity, positive and negative predictive values, accuracy and DOR are indicative of better test performance. DOR values range from 0 to infinity.

  • DOR, diagnostic OR; FP, false positive; FPG, fasting plasma glucose; FN, false negative; HbA1c, glycated hemoglobin; NICE, National Institutefor Health and Care Excellence; NPV, negative predictive value; OGTT, oral glucose tolerance test; PPV, positive predictive value; RBG, random blood glucose; TN, true negative; TP, true positive.