Reference criteria | Test assessed | AUC‡ | 95% CI | P values§ |
2-hour OGTT ≥8.5 mmol/L* | 1-hour OGTT | 0.88 | 0.81 to 0.94 | <0.0001 |
Fasting glucose | 0.86 | 0.80 to 0.91 | <0.0001 | |
Random glucose | 0.60 | 0.51 to 0.69 | 0.035 | |
HbA1c | 0.48 | 0.40 to 0.57 | 0.686 | |
2-hour OGTT ≥7.8 mmol/L† | 1-hour OGTT | 0.85 | 0.80 to 0.91 | <0.0001 |
Fasting glucose | 0.83 | 0.78 to 0.88 | <0.0001 | |
Random glucose | 0.62 | 0.55 to 0.69 | 0.002 | |
HbA1c | 0.48 | 0.40 to 0.55 | 0.567 | |
Fasting glucose ≥5.1 mmol/L* | 1-hour OGTT | 0.77 | 0.71 to 0.82 | <0.0001 |
2-hour OGTT | 0.78 | 0.72 to 0.83 | <0.0001 | |
Random glucose | 0.63 | 0.57 to 0.69 | <0.0001 | |
HbA1c | 0.51 | 0.44 to 0.57 | 0.880 | |
Fasting glucose ≥5.6 mmol/L† | 1-hour OGTT | 0.76 | 0.68 to 0.84 | <0.0001 |
2-hour OGTT | 0.78 | 0.70 to 0.86 | <0.0001 | |
Random glucose | 0.65 | 0.56 to 0.74 | 0.001 | |
HbA1c | 0.51 | 0.41 to 0.60 | 0.867 |
*WHO and †NICE diagnostic criteria. ‡Area under the curve under the null hypothesis=0.5. Test rated excellent for AUC 0.9–1.0, very good for AUC 0.8–0.9, good for AUC 0.70–0.80, sufficient for AUC 0.60–0.70, poor for AUC 0.50–0.60 and invaluable for AUC <0.5 if p<0.05.23 24 §The lower the p value, the higher the clinical relevance of the test.
HbA1c, glycated hemoglobin; NICE, National Institutefor Health and Care Excellence; OGTT, oral glucose tolerance test; ROC, receiver operating characteristic.