Table 4

Association between baseline diabetes medication category and 2-year mortality

Adjusted mortality rate* (95% CI)Risk difference (95% CI)P valuesHR† (95% CI)P values
Full cohort
 Non-sulfonylurea6.5% (5.1 to 7.9)RefRefRefRef
 Sulfonylurea9.7% (7.7 to 11.8)3.2 (0.7 to 5.7) 0.011.38 (1.00 to 1.93)0.05
 No medications5.9% (5.0 to 6.9)−0.6 (−2.2 to 1.1) 0.51.02 (0.77 to 1.35)0.9
Excluding participants with CKD or on dialysis
 Non-sulfonylurea5.5% (4.4 to 6.7)RefRefRefRef
 Sulfonylurea8.4% (5.9 to 10.9)2.9 (0.1 to 5.6)0.041.52 (1.04 to 2.21)0.03
 No medications4.7% (3.7 to 5.6)−0.9 (−2.4 to 0.6)0.241.03 (0.76 to 1.38)0.87
  • *All-cause mortality rate in each medication category in the inverse probability of treatment-weighted population.

  • †HR for 2-year mortality in individuals taking sulfonylureas or no medications compared with those taking non-sulfonylurea medication in inverse probability of treatment-weighted Cox proportional hazards models additionally adjusted for chronic kidney disease and dialysis.

  • CKD, chronic kidney disease ref, reference.