Table 3

Discrimination and reclassification of the original GDRS and the clinical GDRS in the EPIC-Potsdam and GNHIES98 cohort

Performance measureEPIC-PotsdamGNHIES98 cohort
C-indexGDRS (95% CI)0.83 (0.81 to 0.84)0.87 (0.84 to 0.90)*
C-indexClinical GDRS (95% CI)0.87 (0.81 to 0.92)0.91 (0.88 to 0.94)*
NRI (95% CI)0.26 (0.21 to 0.30)
NRInon-cases (95% CI)0.02 (0.01 to 0.02)
NRIcases (95% CI)0.24 (0.19 to 0.28)
  • *In GNHIES98 cohort, ROC-AUC was calculated based on logistic regression.

  • EPIC, European Prospective Investigation into Cancer and Nutrition; GDRS, German Diabetes Risk Score; NRI, net reclassification improvement; ROC-AUC, area under the receiver-operating characteristic curve.