Table 2

HR for severe hypoglycemia events in the ACCORD study

Variable	Unadjusted	Adjusted*
Variable	HR	95% CI	P values	HR	95% CI	P values
Intensive treatment (yes)	2.473	2.074 to 2.949	<0.0001	2.372	1.985 to 2.833	<0.0001
Age, years† (6.8 years)	1.377	1.274 to 1.489	<0.0001	1.134	1.038 to 1.238	0.0054
Black race (yes)	1.746	1.465 to 2.080	<0.0001	1.425	1.188 to 1.708	<0.0001
Education (less than college)	1.477	1.204 to 1.810	0.0002	1.314	1.070 to 1.614	0.0092
Time since diabetes diagnosis, years† (7.7)	1.507	1.407 to 1.615	<0.0001	1.125	1.037 to 1.220	0.0047
Hypoglycemia in the last week (yes)	2.465	2.000 to 3.037	<0.0001	1.361	1.091 to 1.697	0.0063
Creatinine† (mmol/L) (0.020)	1.029	1.023 to 1.035	<0.0001	1.124	1.041 to 1.214	0.0029
Urinary albumin creatinine† (381.1)	1.189	1.136 to 1.245	<0.0001	1.129	1.069 to 1.192	<0.0001
SBP, mm Hg† (17.7)	1.196	1.108 to 1.292	<0.0001	1.175	1.066 to 1.295	0.0012
DBP, mm Hg† (10.9)	0.783	0.721 to 0.850	<0.0001	0.817	0.735 to 0.907	0.0002
Waist circumference, cm† (13.6)	0.895	0.826 to 0.970	0.0071	0.876	0.806 to 0.952	0.0019
Insulin use (yes)	3.222	2.732 to 3.800	<0.0001	2.138	1.765 to 2.590	<0.0001
Sulfonylurea use (yes)	0.392	0.325 to 0.472	<0.0001	0.684	0.561 to 0.834	0.0002
Biguanide use (yes)	0.441	0.376 to 0.518	<0.0001	0.738	0.619 to 0.880	0.0007
Meglitinide use (yes)	1.338	1.074 to 1.667	0.0094	1.286	1.027 to 1.611	0.0285
HMG-CoA reductase inhibitors use (yes)	0.951	0.804 to 1.126	0.5619	0.811	0.683 to 0.964	0.0172
Antihypertensive use (yes)	2.464	1.651 to 3.677	<0.0001	1.899	1.263 to 2.856	0.0021

*Adjusted for all other variables in the risk prediction model.
†HR and 95% CI for 1 SD increment in the continuous variables.
ACCORD, Action to Control Cardiovascular Risk in Diabetes; DBP, diastolic blood pressure; SBP, systolic blood pressure.