Risk of CV events and mortality by refill and guideline adherence level
| CV event | All-cause mortality | CV mortality | ||||||
| Refill adherence | Guideline adherence | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| Crude | Adjusted* | Crude | Adjusted* | Crude | Adjusted* | |||
| Primary prevention, n=107 587 | Low vs high | Low | 1.56 (1.49 to 1.63) | 1.51 (1.44 to 1.59) | 2.25 (2.14 to 2.36) | 2.05 (1.95 to 2.16) | 2.18 (1.99 to 2.39) | 1.92 (1.74 to 2.11) |
| Low vs high | High | 1.49 (1.41 to 1.56) | 1.44 (1.37 to 1.51) | 2.22 (2.11 to 2.34) | 2.01 (1.90 to 2.12) | 2.08 (1.88 to 2.30) | 1.79 (1.61 to 1.99) | |
| Low | Low vs high | 1.08 (1.03 to 1.13) | 1.09 (1.04 to 1.14) | 1.00 (0.96 to 1.05) | 1.05 (1.00 to 1.09) | 1.13 (1.03 to 1.22) | 1.18 (1.08 to 1.28) | |
| High | Low vs high | 1.03 (0.98 to 1.08) | 1.03 (0.98 to 1.08) | 0.99 (0.94 to 1.05) | 1.02 (0.97 to 1.09) | 1.07 (0.96 to 1.19) | 1.10 (0.99 to 1.23) | |
| Secondary prevention, n=14 327 | Low vs high | Low | 1.21 (1.14 to 1.29) | 1.19 (1.11 to 1.27) | 2.26 (2.07 to 2.46) | 1.88 (1.73 to 2.06) | 2.03 (1.80 to 2.30) | 1.66 (1.46 to 1.89) |
| Low vs high | High | 1.21 (1.13 to 1.30) | 1.17 (1.10 to 1.26) | 2.37 (2.17 to 2.59) | 1.97 (1.80 to 2.15) | 2.20 (1.94 to 2.50) | 1.79 (1.57 to 2.03) | |
| Low | Low vs high | 1.00 (0.94 to 1.07) | 1.01 (0.94 to 1.08) | 0.98 (0.91 to 1.05) | 0.99 (0.92 to 1.06) | 0.95 (0.85 to 1.06) | 0.95 (0.86 to 1.06) | |
| High | Low vs high | 1.00 (0.94 to 1.07) | 1.00 (0.94 to 1.06) | 1.03 (0.93 to 1.14) | 1.03 (0.93 to 1.14) | 1.03 (0.89 to 1.18) | 1.03 (0.89 to 1.18) | |
Crude and adjusted HR (with 95% CI) for any CV events, all-cause mortality and CV mortality among patients with type 2 diabetes mellitus by refill and guideline adherence level, as well as prevention type.
*Adjusted for age, sex, socioeconomic status, concurrent medications, as well as clinical and health-related characteristics.
CV, cardiovascular.