Table 3A

Adjusted HR for minor amputations and 95% CI for type 1 diabetes vs controls, time-updated mean HbA1c categories, albuminuria categories, and eGFR categories examined by Cox regression

Amputation below ankleHR (95% CI), p value
Diabetes duration 30yearsDiabetes duration 40yearsDiabetes duration 50yearsDiabetes duration 60years
Overall
Controls (reference)1.001.001.001.00
Group all type 1 diabetes with no prior amputation75.7 (52.6 to 109.0)*86.3 (60.2 to 123.8)*98.4 (67.3 to 143.9)*112.3 (73.7 to 171.0)*
Time-updated mean HbA1c categories
≤52 mmol/mol (≤6.9%)27.3 (16.7 to 44.7)*32.0 (19.7 to 52.0)*37.4 (22.8 to 61.5)*43.7 (25.9 to 74.0)*
53–62 mmol/mol (7.0%–7.8%)45.0 (30.2 to 67.2)*52.7 (35.6 to 77.9)*61.6 (41.1 to 92.4)*72.0 (46.5 to 111.7)*
63–72 mmol/mol (7.9%–8.7%)65.7 (44.6 to 96.7)*76.8 (52.5 to 112.2)*89.8 (60.5 to 133.2)*105.0 (68.3 to 161.5)*
73–82 mmol/mol (8.8%–9.6%)123.4 (83.4 to 182.6)*144.4 (98.3 to 212.1)*168.9 (113.1 to 252.0)*197.5 (127.6 to 305.6)*
≥83 mmol/mol (≥9.7%)299.7 (201.5 to 445.6)*350.5 (237.2 to 517.8)*409.9 (273.0 to 615.4)*479.4 (308.0 to 746.3)*
Time-updated albuminuria categories
Normoalbuminuria48.6 (33.1 to 71.4)*50.4 (34.5 to 73.7)*52.4 (35.1 to 78.2)*54.3 (34.8 to 85.0)*
Microalbuminuria130.6 (87.5 to 195.1)*135.5 (91.7 to 200.2)*140.6 (93.6 to 211.2)*145.9 (93.3 to 228.1)*
Macroalbuminuria209.2 (139.4 to 314.1)*217.0 (146.2 to 322.0)*225.2 (149.5 to 339.4)*233.7 (149.2 to 366.2)*
CKD stage 5623.7 (408.4 to 952.6)*646.8 (428.6 to 975.9)*671.5 (439.1 to 1026.8)*696.7 (439.2 to 1105.2)*
Time-updated eGFR categories
CKD stage 1 (eGFR ≥90)45.9 (30.6 to 69.0)*47.2 (31.5 to 70.7)*48.5 (31.6 to 74.5)*49.8 (31.0 to 80.2)*
CKD stage 2 (eGFR 60–89)75.3 (51.2 to 110.8)*77.3 (52.9 to 113.2)*79.5 (53.1 to 118.9)*81.7 (52.1 to 128.0)*
CKD stage 3 (eGFR 30–59)160.5 (106.4 to 242.1)*164.9 (110.6 to 245.9)*169.5 (111.9 to 256.7)*174.2 (110.6 to 274.5)*
CKD stage 4 (eGFR 15–29)190.8 (111.7 to 325.9)*196.0 (115.7 to 332.2)*201.5 (117.4 to 345.7)*207.2 (117.0 to 366.8)*
CKD stage 5 (eGFR <15, dialysis or transplantation)623.1 (408.2 to 950.9)*640.1 (424.0 to 966.4)*658.0 (429.3 to 1008.5)*676.2 (424.5 to 1077.1)*
  • All models are adjusted for time-updated age, sex, born in Sweden, maximum educational level, baseline comorbidities and time-updated diabetes duration centered at 30, 40, 50 and 60 years.

  • *Significant at p<0.0001.