Table 3B

Adjusted HR for major amputations and 95% CIs for type 1 diabetes vs controls, time-updated mean HbA1c categories, albuminuria categories, and eGFR categories examined by Cox regression

Amputation above ankleHR (95% CI), p value
Diabetes duration 30yearsDiabetes duration 40yearsDiabetes duration 50yearsDiabetes duration 60years
Overall
Controls (reference)1.001.001.001.00
Group all type 1 diabetes with no prior amputation21.4 (16.6 to 27.5)*27.3 (21.5 to 34.5)*34.8 (27.1 to 44.7)*44.4 (33.2 to 59.4)*
Time-updated mean HbA1c categories
≤52 mmol/mol (≤6.9%)8.1 (5.3 to 12.2)*10.8 (7.3 to 16.0)*14.4 (9.7 to 21.5)*19.3 (12.6 to 29.4)*
53–62 mmol/mol (7.0%–7.8%)13.2 (9.8 to 17.8)*17.6 (13.3 to 23.3)*23.5 (17.7 to 31.4)*31.5 (22.8 to 43.3)*
63–72 mmol/mol (7.9%–8.7%)18.6 (14.0 to 24.8)*24.9 (19.1 to 32.5)*33.3 (25.3 to 43.8)*44.5 (32.6 to 60.7)*
73–82 mmol/mol (8.8%–9.6%)30.6 (22.8 to 41.1)*40.9 (30.9 to 54.0)*54.6 (40.9 to 73.0)*73.0 (52.7 to 101.2)*
≥83 mmol/mol (≥9.7%)78.4 (58.1 to 105.9)*104.8 (78.8 to 139.4)*140.0 (104.0 to 188.5)*187.1 (134.1 to 261.1)*
Time-updated albuminuria categories
Normoalbuminuria13.6 (10.2 to 18.1)*16.5 (12.6 to 21.6)*20.1 (15.2 to 26.6)*24.4 (17.6 to 33.7)*
Microalbuminuria26.2 (19.0 to 36.2)*31.8 (23.6 to 42.9)*38.7 (28.5 to 52.4)*47.0 (33.5 to 65.9)*
Macroalbuminuria59.3 (43.4 to 80.9)*72.0 (54.1 to 95.9)*87.6 (65.3 to 117.4)*106.4 (76.5 to 148.0)*
CKD stage 5194.1 (139.8 to 269.5)*235.9 (173.9 to 320.0)*286.7 (210.1 to 391.4)*348.5 (246.7 to 492.3)*
Time-updated eGFR categories
CKD stage 1 (eGFR ≥90)15.4 (11.2 to 21.2)*19.0 (14.0 to 25.7)*23.3 (16.9 to 32.1)*28.6 (19.9 to 41.1)*
CKD stage 2 (eGFR 60–89)16.7 (12.4 to 22.6)*20.6 (15.6 to 27.1)*25.2 (19.0 to 33.6)*31.0 (22.4 to 43.0)*
CKD stage 3 (eGFR 30–59)26.7 (19.1 to 37.3)*32.8 (24.1 to 44.5)*40.2 (29.6 to 54.7)*49.5 (35.3 to 69.3)*
CKD stage 4 (eGFR 15–29)55.0 (35.5 to 85.4)*67.6 (44.5 to 102.8)*83.1 (54.5 to 126.6)*102.1 (65.3 to 159.6)*
CKD stage 5 (eGFR <15, dialysis or transplantation)185.3 (132.9 to 258.5)*227.7 (167.5 to 309.6)*279.6 (204.6 to 382.2)*343.7 (242.9 to 486.3)*
  • All models are adjusted for time-updated age, sex, born in Sweden, maximum educational level, baseline comorbidities and time-updated diabetes duration centered at 30, 40, 50 and 60 years.

  • *Significant at p<0.0001.

  • CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c.