Changes in metabolic parameters at 12 weeks in study tertiles
| Lowest tertile (n=14) | Middle tertile (n=14) | Highest tertile (n=14) | P value† | |
| Body weight (kg) | −6.9 (−4.2 to −8.9) | −8.3 (−5.2 to −12.2) | −10.4 (−7.6 to −14.4) | 0.018* |
| BMI (kg/m2) | −2.5 (−1.5 to −3.3) | −2.7 (−1.6 to −3.9) | −3.9 (−2.8 to −4.9) | 0.012* |
| A1C (%) | −0.5 (−0.2 to −1.2) | −0.8 (−0.3 to −2) | −1.25 (−0.6 to −3.1) | 0.048* |
| Systolic blood pressure (mm Hg) | 1 (−16 to 6) | −3.5 (−13 to 8) | −12 (−17 to −5) | 0.1 |
| Diastolic blood pressure (mm Hg) | 0.5 (−4 to 4) | −3.5 (−10 to 0) | −5 (−10 to 0) | 0.1 |
| Total cholesterol (mg/dL) | −12 (−18.5 to −4.5) | −16 (−21 to 5) | −19 (−37 to −8) | 0.2 |
| LDL-cholesterol (mg/dL) | −11.5 (−15 to 1) | −0.5 (−13 to 13) | −7 (−20 to 5) | 0.7 |
| HDL-cholesterol (mg/dL) | 2 (0 to 8) | 3.5 (−1 to 4) | −2 (−5 to 2) | 0.06 |
| Triglycerides (mg/dL) | −12 (−28 to 14) | −31.5 (−55 to −10) | −30 (−75 to −13) | 0.08 |
| Weight-adjusted insulin dose (units/kg/day)‡ | −0.18 (−0.34 to −0.12) | −0.38 (−0.44 to −0.23) | −0.2 (−0.8 to 0.17) | 0.5 |
Data are median (IQR).
*P<0.05.
†Non-parametric test for trend across ordered groups, an extension of the Wilcoxon rank-sum test.
‡For insulin-treated subjects.
BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein.