Semaglutide 0.5 mg | Insulin glargine U100 | Difference | |

Discounted life expectancy (years) | 18.35 (0.27) | 18.15 (0.29) | +0.20 |

Discounted quality-adjusted life expectancy (QALYs) | 12.05 (0.18) | 11.85 (0.19) | +0.19 |

Discounted direct costs (€) | 26 780 (1054) | 24 627 (1136) | +2152 |

Discounted combined costs (€) | 46 860 (1903) | 45 911 (1967) | +949 |

ICER based on direct costs | €11 310 per QALY gained | ||

ICER based on combined costs | €4988 per QALY gained |

Semaglutide 1 mg | Insulin glargine U100 | Difference | |

Discounted life expectancy (years) | 18.44 (0.27) | 18.15 (0.29) | +0.28 |

Discounted quality-adjusted life expectancy (QALYs) | 12.12 (0.18) | 11.85 (0.19) | +0.27 |

Discounted direct costs (€) | 26 654 (1112) | 24 627 (1136) | +2027 |

Discounted combined costs (€) | 46 044 (1934) | 45 911 (1967) | +133 |

ICER based on direct costs | €7515 per QALY gained | ||

ICER based on combined costs | €495 per QALY gained |

Once-weekly semaglutide 0.5 mg | Dulaglutide 0.75 mg | Difference | |

Discounted life expectancy (years) | 17.56 (0.29) | 17.51 (0.27) | +0.06 |

Discounted quality-adjusted life expectancy (QALYs) | 11.53 (0.19) | 11.46 (0.18) | +0.07 |

Discounted direct costs (€) | 26 133 (1070) | 25 819 (1124) | +314 |

Discounted combined costs (€) | 46 160 (1935) | 46 606 (2013) | −446 |

ICER based on direct costs | €4671 per QALY gained | ||

ICER based on combined costs | Once-weekly semaglutide 0.5 mg dominant |

Semaglutide 1 mg | Dulaglutide 1.5 mg | Difference | |

Discounted life expectancy (years) | 17.69 (0.27) | 17.55 (0.28) | +0.14 |

Discounted quality-adjusted life expectancy (QALYs) | 11.63 (0.18) | 11.50 (0.18) | +0.13 |

Discounted direct costs (€) | 25 945 (1025) | 25 565 (1070) | +381 |

Discounted combined costs (€) | 45 365 (1880) | 45 820 (1922) | −455 |

ICER based on direct costs | €2861 per QALY gained | ||

ICER based on combined costs | Once-weekly semaglutide 1 mg dominant |

Values are means (SD).

€, 2017 euros (EUR); ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life year.