Table 1

Effects of empagliflozin on metabolic parameters at 8 weeks of treatment

NCHFDHFD+Empa
Fed blood glucose145.0±6.9176.9±4.4**155.1±5.9 #
Plasma TG (mg/dL)28.1±4.550.5±8.7*29.9±6.0 #
Plasma TC (mg/dL)80.5±3.6181.1±10.8**149.1±6.4 #
Plasma NEFA (mEq/L)0.20±0.040.27±0.070.22±0.06
Plasma ALT (IU/L)10.6±1.830.5±3.3**21.6±2.2 ##
Plasma AST (IU/L)4.9±1.021.4±1.5**11.1±2.1 #
Plasma ketone body (mmol/L)0.91±0.030.95±0.031.18±0.05 ##
Plasma glycerol (μM)376.9±24.7364.9±36.4487.4±31.3 ##
Plasma TBARS (μM)4.2±0.9611.9±2.2**5.9±0.8 #
Plasma 8-OHdG (ng/mL)10.8±1.845.7±6.6**22.6±4.7 #
Plasma creatinine (mg/dL)1.3±0.11.5±0.31.54±0.2
  • Shown are blood parameters of mice fasted for 16 hours. Data were obtained from mice aged 24 weeks on different diets. Data are presented as means±SEM, n=6–8. *P<0.05 and **p<0.01, respectively, for comparisons with NC-fed mice; #p<0.05 and ##p<0.01, respectively, for comparisons with HFD-fed mice.

  • ALT, alanine aminotransferase; AST, aspartate aminotransferase; HFD, high-fat diet; NC, normal chow; NEFA, non-esterified fatty acids; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; TBARS, thiobarbituric acid-reactive substrates ; TC, total cholesterol; TG, triglyceride.