Discriminatory accuracy and cut-off values for triglyceride/HDL-C ratio, LAP, VAI, and TyG index in identifying subjects with insulin resistance defined as the bottom quartile of MFFM values
| Sensitivity | Specificity | Positive predictive value | Negative predictive value | AUC (95% CI) | P value* | Diagnostic likelihood ratio (+) | Youden index | Cut-off | |
| Triglyceride/HDL-C ratio | 0.82 | 0.48 | 0.35 | 0.89 | 0.693 (0.646 to 0.729) | 0.01 | 1.60 | 0.309 | 0.57 |
| LAP index | 0.70 | 0.65 | 0.40 | 0.86 | 0.728 (0.692 to 0.762) | NA | 2.00 | 0.350 | 3.84 |
| VAI | 0.73 | 0.54 | 0.35 | 0.86 | 0.688 (0.650 to 0.724) | 0.002 | 1.61 | 0.276 | 0.34 |
| TyG index | 0.59 | 0.70 | 0.40 | 0.84 | 0.688 (0.650 to 0.723) | 0.005 | 2.04 | 0.305 | 9.36 |
*P value of receiver operating characteristic (ROC) test between each marker and benchmark LAP index, respectively.
AUC, area under the ROC curve; HDL-C, high-density lipoprotein cholesterol; LAP, lipid accumulation product; NA, not applicable; TyG, triglycerides × fasting glucose; VAI, visceral adiposity index.