Discriminatory accuracy and cut-off values for triglyceride/HDL-C ratio, LAP, VAI, and TyG index in identifying individuals with subclinical vascular damage
| Sensitivity | Specificity | Positive predictive value | Negative predictive value | AUC (95% CI) | P value* | Diagnostic likelihood ratio (+) | Youden index | Cut-off | |
| Vascular atherosclerosis defined as IMT>0.9 mm | |||||||||
| Triglyceride/HDL-C ratio | 0.950 | 0.412 | 0.134 | 0.989 | 0.701 (0.656 to 0.742) | 0.15 | 1.62 | 0.362 | 0.499 |
| LAP index | 0.900 | 0.494 | 0.146 | 0.981 | 0.742 (0.699 to 0.782) | NA | 1.78 | 0.394 | 3.623 |
| VAI | 0.750 | 0.601 | 0.153 | 0.962 | 0.705 (0.661 to 0.747) | 0.12 | 1.88 | 0.351 | 0.484 |
| TyG index | 0.825 | 0.592 | 0.163 | 0.972 | 0.739 (0.696 to 0.779) | 0.91 | 2.02 | 0.417 | 9.192 |
| Increased vascular stiffness defined as pulse pressure >60 mmHg | |||||||||
| Triglyceride/HDL-C ratio | 0.662 | 0.473 | 0.169 | 0.897 | 0.551 (0.510 to 0.590) | 0.001 | 1.26 | 0.136 | 0.659 |
| LAP index | 0.721 | 0.500 | 0.189 | 0.917 | 0.614 (0.574 to 0.652) | NA | 1.44 | 0.221 | 3.664 |
| VAI | 0.744 | 0.415 | 0.171 | 0.909 | 0.562 (0.522 to 0.602) | 0.001 | 1.27 | 0.276 | 0.177 |
| TyG index | 0.744 | 0.417 | 0.171 | 0.910 | 0.579 (0.539 to 0.618) | 0.04 | 1.28 | 0.161 | 8.987 |
*P value of receiver operating characteristic (ROC) test between each marker and benchmark LAP index, respectively.
AUC, area under the ROC curve; HDL-C, high-density lipoprotein cholesterol; IMT, intima-media thickness; LAP, lipid accumulation product; NA, not applicable; TyG, triglycerides × fasting glucose; VAI, visceral adiposity index.