| Li et al50 | China | STZ-treated diabetic mice. | Central cornea epithelium debrided via Alger brush. | Safflower extract and aceglutamide injection reduces ameliorates diabetic cornea neuropathy. Its protective effect is associated with the elevated cornea epithelial secretion of vascular endothelial growth factor-B (VEGF–B), nerve growth factor (NGF) and Glial cell line-derived neurotrophic factor (GDNF).
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| Morishige et al51 | Japan | STZ-treated diabetic rats. | A portion of corneal epithelium is debrided by a scraper. | Administration of Pro-His-Ser-Arg-Asn significantly facilitated healing of corneal epithelial wounds in both diabetic rats and controls. The effect is postulated to be due to increased cornea epithelial cell migration response after injury.
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| Atiba et al28 | Egypt | STZ-treated diabetes rats. | Alkali-burn injury with 0.01 M NaOH on it for 45 s. | |
| Zhang et al23 | China | STZ-treated diabetic mice. | Central cornea epithelium debrided by Alger brush. | Topical application of Resolvin D1 (RvD1) promoted corneal epithelial wound healing and reduced ocular surface inflammation after injury in diabetic eyes. Furthermore, RvD1 promoted regeneration of corneal nerves and significantly sped up restoration of normal corneal sensation after injury. The underlying mechanism is purported to be related to RvD1’s ability in reducing AGE-mediated oxidative stress.
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| He et al57 | USA | STZ-treated diabetic mice. | A 2 mm diameter cornea epithelial injury with corneal rust ring remover. | Topical treatment with pigment epithelium-derived factor+docosahexaenoic acid promoted corneal nerve regeneration and epithelial wound healing after injury in diabetic mice. Furthermore, it increased tear production and attenuated the ocular surface inflammatory response after injury.
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| Sun et al58 | USA | STZ-treated diabetic mice | Corneal epithelial debridement. | |