Table 3

ORs (95% CIs) for tertiles of activin A per clinical characteristics and laboratory tests in combined cohorts with diabetes

Logistic regression tableOverall diabetes cohort (n=206)
Unadjusted variablesMedium vs low tertileHigh vs low tertile
Unadjusted OR (95% CI)P valueUnadjusted OR (95% CI)P value
eGFR calculations
 CKD-EPI eGFR, per 10 mL/min/1.73 m20.73 (0.63 to 0.85)<0.00010.47 (0.37 to 0.59)<0.0001
 MDRD eGFR, per 10 mL/min/1.73 m20.79 (0.69 to 0.90)0.00040.44 (0.34 to 0.57)<0.0001
Clinical features and laboratory measurements
 Age, per 10 years1.98 (1.37 to 2.85)0.00031.94 (1.36 to 2.77)0.0003
 BMI, kg/m21.03 (0.97 to 1.10)0.41.08 (1.01 to 1.15)0.02
 Hemoglobin, g/L0.96 (0.94 to 0.99)0.0030.94 (0.91 to 0.96)<0.0001
 Hemoglobin A1c, %0.92 (0.72 to 1.17)0.51.13 (0.88 to 1.46)0.3
 Albumin, per 0.01 g/dL0.98 (0.96 to 0.99)0.0010.96 (0.95 to 0.97)<0.0001
 Sodium, mmol/L1.09 (0.96 to 1.24)0.21.11 (0.98 to 1.25)0.08
 BUN, mg/dL1.09 (1.04 to 1.14)0.00011.17 (1.11 to 1.23)<0.0001
 PTH, per 10 pg/mL1.02 (1.004 to 1.04)0.011.05 (1.03 to 1.07)<0.0001
 UACR, mg/g1.004 (1.001 to 1.01)0.0081.007 (1.0 to 1.01)0.001
 Log UACR, per log1.49 (1.18 to 1.87)0.0012.04 (1.60 to 2.61)<0.0001
 CRP, mg/L1.03 (0.96 to 1.09)0.41.001 (0.93 to 1.07)0.9
 Log CRP, per log0.95 (0.84 to 1.07)0.40.86 (0.77 to 0.95)0.004
eGFR-adjusted variables*
 Clinical features and laboratory measurements
  Age, per 10 years1.48 (0.99 to 2.22)0.061.08 (0.67 to 1.75)0.8
  BMI, per kg/m21.05 (0.98 to 1.12)0.11.08 (0.98 to 1.18)0.1
  Hemoglobin, per g/L0.98 (0.95 to 1.003)0.080.96 (0.93 to 0.99)0.02
  Albumin, per 0.01 g/dL0.98 (0.96 to 0.99)0.030.98 (0.96 to 0.99)0.003
  BUN, per mg/dL1.04 (0.98 to 1.12)0.21.04 (0.98 to 1.11)0.2
  PTH, per 10 pg/mL1.01 (0.99 to 1.02)0.51.02 (1.002 to 1.04)0.03
  Log UACR, per log1.42 (1.12 to 1.81)0.0041.56 (1.16 to 2.09)0.03
  • NGSP hemoglobin A1c converter http://www.ngsp.org/convert1.asp may be used to calculate hemoglobin A1c values from % to mmol/mol. Values represent mean (SD) or number (%).

  • P-values with bold font represent statistically significant values (<0.05).

  • *All variables adjusted for CKD-EPI eGFR including age, sex, race and serum creatinine.

  • BMI, body mass index; BUN, blood urea nitrogen; CKD, chronic kidney disease; CRP, C reactive protein; eGFR, estimated glomerular filtration rate; MDRD, modification of diet renal disease; PTH, parathyroid hormone; UACR, urine albumin-to-creatinine ratio.