Demographic characteristics and clinical laboratory tests in participants with diabetes and controls at Mayo and Galway sites
| Characteristic | Mayo cohort | Galway cohort | Diabetes cases | ||||
| Controls | Diabetes cases | P value | Controls | Diabetes cases | P value | *P value | |
| (n=12) | (n=46) | (n=64) | (n=160) | ||||
| Clinical features and laboratory measurements | |||||||
| Age, years | 61.3 (5.37) | 67.4 (7.29) | 0.007 | 45.4 (10.37) | 65.8 (12.36) | <0.0001 | 0.5 |
| Female sex, % | 8 (66.7%) | 13 (28.3%) | 0.01 | 40 (62.5%) | 47 (29.4%) | <0.0001 | 0.9 |
| White race, % | 12 (100%) | 39 (84.8%) | 0.1 | 64 (100%) | 154 (96.3%) | 0.1 | 0.005 |
| BMI, kg/m2 | 27.4 (5.01) | 33.6 (5.60) | 0.002 | 24.4 (3.27) | 31.4 (5.74) | <0.0001 | 0.01 |
| Hemoglobin, g/L | 140.75 (12.98) | 130.87 (116.84) | 0.1 | 138.98 (10.85) | 132.30 (16.81) | 0.01 | 0.5 |
| Albumin, g/dL | 4.5 (0.24) | 4.2 (0.34) | 0.002 | 4.7 (0.29) | 4.5 (0.31) | <0.0001 | <0.0001 |
| Creatinine, mg/dL | 0.9 (0.15) | 1.9 (0.82) | <0.0001 | 0.9 (0.16) | 1.3 (0.64) | <0.0001 | <0.0001 |
| eGFR calculations | |||||||
| CKD-EPI eGFR, mL/min/1.73 m2 | 77.0 (11.44) | 41.3 (18.95) | <0.0001 | 92.8 (14.05) | 63.1 (28.61) | <0.0001 | <0.0001 |
| MDRD eGFR, mL/min/1.73 m2 | 76.6 (11.88) | 43.3 (19.45) | <0.0001 | 83.5 (13.86) | 63.0 (30.31) | <0.0001 | <0.0001 |
| Activin A | |||||||
| Activin A, pg/mL | 355.4 (79.80) | 508.1 (190.36) | 0.007 | 241.3 (67.60) | 392.2 (169.41) | <0.0001 | <0.0001 |
Values represent mean (SD) or number (%).
P-values with bold font represent statistically significant values (<0.05).
*Comparison between Mayo and Galway diabetes cases.
BMI, body mass index; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate;MDRD, modification of diet renal disease.