Clinical outcomes in OSA versus non-OSA groups according to diabetes status
| Variables | Diabetes | No diabetes | ||||||
| Unadjusted HR (95% CI) | P value | Adjusted HR* (95% CI) | P value | Unadjusted HR (95% CI) | P value | Adjusted HR* (95% CI) | P value | |
| MACCE | 2.89 (1.36 to 6.17) | 0.006 | 2.49 (1.16 to 5.35) | 0.02 | 1.06 (0.59 to 1.90) | 0.85 | 0.94 (0.51 to 1.75) | 0.85 |
| Cardiovascular death† | 5.11 (0.60 to 43.77) | 0.14 | – | – | – | 0.25 | – | – |
| Myocardial infarction† | 2.75 (0.28 to 26.72) | 0.38 | – | – | 0.16 (0.02 to 1.31) | 0.09 | – | – |
| Stroke† | 3.98 (0.44 to 35.73) | 0.22 | – | – | 0.95 (0.13 to 6.74) | 0.96 | – | – |
| Ischemia-driven revascularization | 1.52 (0.50 to 4.66) | 0.47 | 1.50 (0.48 to 4.68) | 0.49 | 1.64 (0.55 to 4.89) | 0.38 | 1.35 (0.42 to 4.30) | 0.62 |
| Hospitalization for unstable angina | 2.49 (0.97 to 6.38) | 0.06 | 2.41 (0.93 to 6.26) | 0.07 | 1.56 (0.71 to 3.40) | 0.27 | 1.45 (0.64 to 3.33) | 0.38 |
| Hospitalization for heart failure† | – | 0.61 | – | – | 0.64 (0.11 to 3.85) | 0.63 | – | – |
| All repeat revascularization | 1.81 (0.67 to 4.90) | 0.25 | 1.86 (0.68 to 5.14) | 0.23 | 1.13 (0.56 to 2.28) | 0.74 | 1.08 (0.51 to 2.28) | 0.85 |
| Composite of all events | 2.89 (1.40 to 5.93) | 0.004 | 2.52 (1.21 to 5.22) | 0.01 | 1.02 (0.62 to 1.67) | 0.94 | 0.95 (0.56 to 1.62) | 0.86 |
*Model adjusted for age, sex, body mass index, hypertension, and diabetes mellitus, clinical presentation (acute myocardial infarction vs unstable angina).
†Univariate and/or multivariate Cox regression was not done due to no or few number of events.
MACCE, major adverse cardiovascular and cerebrovascular event; OSA, obstructive sleep apnea.