Table 1

Clinical characteristics of study participants. All continuous numerical data are presented as median (range) unless otherwise stated. In one patient who was taking gliclazide and not glibenclamide, dose was converted to glibenclamide equivalent using % maximum dose according to British National Formulary

Clinical featureKCNJ11 casesNon-diabetic controlsP value
Age (years)39.1 (24.4–41.0)39.6 (24.2–41.8)0.60
Sex, male (%)1 (20)1 (20)1.00
BMI22.9 (22.4–26.8)24.6 (23.9–25.6)0.60
Fasting glucose (mmol/mol)10.1 (8.6–11.9)5.3 (4.8–5.5)0.009
KCNJ11 mutation4 R201H, 1 R201CN/AN/A
SU dose (mg/kg/day glibenclamide)0.28 (0.07–1.21)N/AN/A
HbA1c (%)6.9 (6.5–7.9)N/AN/A
HbA1c (mmol/mol)52 (48–63)N/AN/A
  • BMI, body mass index; N/A, not applicable; SU, sulfonylurea.