C
Age (years)	0.077	0.028	1.06 (1.02 to 1.11)	0.006
DR and/or microalbuminuria				0.001
Microalbuminuria	0.816	0.407	2.26 (1.02 to 5.02)
DR (no–mild/moderate–severe)	2.144	1.096	8.53 (1.05 to 69.12)
Microalbuminuria and DR	2.202	1.096	9.04 (1.05 to 77.57)
Constant	−4.873	1.842

Dependent variable: combined endpoint. Independent variables included in the model: age, gender, diabetes duration, GFR, homocysteine, hypertension (no/yes), dyslipidemia (no/yes), and the presence of microalbuminuria and/or DR (no or mild /moderate to severe).