Table 1

The impact of glycemic traits on breast cancer risk in Breast Cancer Association Consortium using Mendelian randomization

All SNPs	Inverse variance weighting with multiplicative random effects			MR-Egger				Weighted median
All SNPs	OR	95% CI	I²	OR	95% CI	Intercept	Intercept p value	OR	95% CI
Glucose (mmol/L) (n=21)	1.03	0.85 to 1.25	0.763	1.02	0.66 to 1.57	0.001	0.94	0.99	0.85 to 1.14
HbA1c (%) (n=32)	1.02	0.73 to 1.45	0.843	1.23	0.64 to 2.37	−0.004	0.53	1.07	0.86 to 1.33
Type 2 diabetes (n=147)	0.98	0.95 to 1.01	0.707	1.01	0.95 to 1.08	−0.003	0.24	1.02	0.99 to 1.06
Excluding pleiotropic SNPs
Glucose (mmol/L) (n=11)	1.00	0.81 to 1.23	0.72	1.09	0.69 to 1.71	−0.004	0.68	0.94	0.81 to 1.10
HbA1c (%) (n=19)	1.06	0.91 to 1.23	0.00	1.12	0.85 to 1.49	−0.002	0.62	1.06	0.85 to 1.32
Type 2 diabetes (n=108)	0.97	0.94 to 1.01	0.585	0.90	0.80 to 1.01	0.005	0.18	0.97	0.93 to 1.01