Pooled HRs for incident diabetes association with prediabetes status at baseline and Harrell’s C-statistics for predicting 5-year risk of diabetes associated with prediabetes status at baseline
| Prediabetes definition | Multiple adjusted* | ||||
| N | HR (95% CI)† | I2 (%) | C-statistics (95% CI)† | I2 (%) | |
| WHO-FPG‡ | 73 151 | 5.54 (4.31 to 7.12) | 93.9 | 0.789 (0.772 to 0.807) | 63.5 |
| ADA-FPG‡ | 73 151 | 4.17 (3.36 to 5.17) | 93.3 | 0.803 (0.787 to 0.819) | 62.2 |
| 2hPG | 12 846 | 3.78 (3.11 to 4.60) | 66.4 | 0.793 (0.774 to 0.812) | 0 |
| ADA-HbA1c | 19 375 | 7.81 (4.32 to 14.14) | 94.9 | 0.811 (0.724 to 0.899) | 97.9 |
| IEC-HbA1c | 19 375 | 8.36 (4.88 to 14.33) | 93.9 | 0.802 (0.729 to 0.874) | 96.2 |
*Age, sex, body mass index, systolic blood pressure, smoking and family history of diabetes.
†Normal (non-prediabetes or diabetes) was the reference group, see table 1 for the respective definitions.
‡Family history of diabetes was not adjusted for MESA and Aichi.
ADA, American Diabetes Association; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; 2hPG, 2-hour postload plasma glucose; IEC, International Expert Committee.