Cut-point | Area under the curve | Sensitivity (%) | Specificity (%) | Positive predicted value (%) | Negative predicted value (%) | Baseline prediabetes prevalence (%) | Age-adjsuted and sex-adjusted HR | Population attributable fraction (%) | |
FPG (mmol/L) | |||||||||
Derived from ROC | 5.6* | 0.706 (0.697 to 0.715) | 64.1 (62.3 to 65.9) | 77.0 (76.7 to 77.3) | 9.8 (9.4 to 10.2) | 98.2 (98.1 to 98.3) | 24.6 | 5.24 | 51.1 |
WHO-FPG | 6.1* | 0.665 (0.656 to 0.674) | 39.1 (37.3 to 41.0) | 93.8 (93.7 to 94.0) | 19.9 (18.8 to 20.9) | 97.5 (97.4 to 97.6) | 7.4 | 7.50 | 32.5 |
ADA-FPG | 5.6* | 0.706 (0.697 to 0.715) | 64.1 (62.3 to 65.9) | 77.0 (76.7 to 77.3) | 9.8 (9.4 to 10.2) | 98.2 (98.1 to 98.3) | 24.6 | 5.24 | 51.1 |
Derived from spline | 5.1* | 0.641 (0.634 to 0.648) | 83.9 (82.4 to 85.2) | 44.3 (44.0 to 44.7) | 5.6 (5.3 to 5.8) | 98.6 (98.5 to 98.7) | 56.7 | 3.84 | 61.7 |
2hPG (mmol/L) | |||||||||
Derived from ROC | 7.0* | 0.715 (0.695 to 0.734) | 62.0 (58.1 to 65.9) | 80.9 (80.2 to 81.6) | 13.5 (12.2 to 14.8) | 97.8 (97.5 to 98.1) | 21.1 | 4.00 | 38.8 |
WHO/ADA-2hPG | 7.8* | 0.700 (0.680 to 0.720) | 50.2 (46.2 to 54.3) | 89.8 (89.2 to 90.3) | 19.0 (17.2 to 21.0) | 97.4 (97.1 to 97.7) | 12.1 | 4.63 | 30.5 |
HbA1c (%) | |||||||||
Derived from ROC | 5.6 | 0.762 (0.747 to 0.777) | 72.8 (69.8 to 75.7) | 79.6 (79.1 to 80.2) | 14.3 (13.3 to 15.4) | 98.4 (98.2 to 98.6) | 22.7 | 10.12 | 67.4 |
ADA-HbA1c | 5.7 | 0.748 (0.732 to 0.764) | 64.7 (61.5 to 67.9) | 85.0 (84.4 to 85.5) | 16.7 (15.5 to 18.0) | 98.1 (97.9 to 98.3) | 17.3 | 9.76 | 60.2 |
IEC-HbA1c | 6.0 | 0.679 (0.663 to 0.695) | 40.4 (37.2 to 43.8) | 95.4 (95.0 to 95.7) | 28.9 (26.4 to 31.5) | 97.2 (96.9 to 97.4) | 6.2 | 10.72 | 37.6 |
Derived from spline | 5.0 | 0.590 (0.582 to 0.598) | 94.9 (93.3 to 96.3) | 23.0 (22.4 to 23.6) | 5.44 (5.09 to 5.81) | 99.0 (98.6 to 99.3) | 77.8 | 4.75 | 74.5 |
*To convert glucose from mmol/L to mg/dL, divide value by 0.0555.
ADA, American Diabetes Association; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; 2hPG, 2-hour postload plasma glucose; IEC, International Expert Committee.