The impact of glycemic traits on breast cancer risk in UK Biobank using Mendelian randomization
| All SNPs | Inverse variance weighting with multiplicative random effects | MR-Egger | Weighted median | ||||||
| OR | 95% CI | I2 | OR | 95% CI | Intercept | Intercept p value | OR | 95% CI | |
| Glucose (mmol/L) (n=21) | 1.05 | 0.82 to 1.33 | 0.365 | 0.85 | 0.50 to 1.42 | 0.008 | 0.38 | 1.06 | 0.80 to 1.39 |
| HbA1c (%) (n=34) | 1.08 | 0.64 to 1.81 | 0.719 | 1.11 | 0.42 to 2.94 | −0.001 | 0.94 | 1.28 | 0.81 to 2.02 |
| Type 2 diabetes (n=159) | 0.98 | 0.95 to 1.03 | 0.292 | 1.00 | 0.92 to 1.09 | −0.001 | 0.63 | 1.04 | 0.98 to 1.10 |
| Excluding pleiotropic SNPs | |||||||||
| Glucose (mmol/L) (n=11) | 1.02 | 0.77 to 1.35 | 0.35 | 0.82 | 0.46 to 1.47 | 0.011 | 0.42 | 1.05 | 0.77 to 1.42 |
| HbA1c (%) (n=21) | 1.15 | 0.71 to 1.86 | 0.608 | 1.00 | 0.41 to 2.43 | 0.004 | 0.72 | 1.28 | 0.81 to 2.00 |
| Type 2 diabetes (n=120) | 1.00 | 0.95 to 1.06 | 0.238 | 1.02 | 0.88 to 1.17 | −0.001 | 0.83 | 1.03 | 0.96 to 1.11 |
SNP, single-nucleotide polymorphism.